Amyotrophic lateral sclerosis classification: Difference between revisions
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Revision as of 12:30, 24 August 2012
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Amyotrophic lateral sclerosis Microchapters |
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Differentiating Amyotrophic lateral sclerosis from other Diseases |
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Diagnosis |
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Amyotrophic lateral sclerosis classification On the Web |
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American Roentgen Ray Society Images of Amyotrophic lateral sclerosis classification |
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Risk calculators and risk factors for Amyotrophic lateral sclerosis classification |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Classification
ALS is classified into three general groups, familial ALS, sporadic ALS and Guamanian ALS.
- "Familial ALS" accounts for approximately 5%-10% of all ALS cases and is caused by genetic factors. Of these approximately 10% are linked to a mutation in Superoxide dismutase (SOD1), a copper/zinc dependant dismutase that is responsible for scavenging free radicals.
- Most of the remaining 90-95% of cases are classified as "sporadic ALS" and have no known hereditary component.
- A third type, called "Guamanian ALS", represents a small cluster of cases concentrated on the Pacific island of Guam.