Clinical depression causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Causes

Common Causes

• Addison's Disease
• Alzheimer's Disease
• Bipolar Disease
• Brain tumor
• Chronic Renal Failure
• Cushing's Syndrome
• Dementia
• Diabetes Mellitus
• Drugs, toxins
• Epilepsy
• HIV infection
• Huntington's Chorea
• Hypercalcemia
• Hypokalemia
• Hyponatremia
• Hypothyroidism

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• Influenza
• Menopause
• Mononucleosis
• Multiple Sclerosis
• Myocardial Infarction
• Neoplasm
• Parkinson's Disease
• Pernicious anemia
• Seasonal Affective Disorder
• Stroke
• Subdural hematoma
• Syphilis
• Thyrotoxicosis
• Viral Hepatitis
• Vitamin B12 Deficiency

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Causes by Organ System

Cardiovascular	Basilar artery insufficiency, Binswanger's Disease, Vascular malformations of the brain,
Chemical / poisoning	Acute Pesticide poisoning, Amitrole, Black locust poisoning, Bottlebrush buckeye poisoning, California buckeye poisoning, Coastal leucothoe poisoning, Cocaine abuse, Crack addiction, Cycad nut poisoning, Dexedrine overdose, Ecstasy , Fetterbush poisoning, Florida leucothoe poisoning, Inhalant abuse, Lead poisoning,Marijuana addiction Opioid addiction, OxyContin withdrawal, Pernettya poisoning, Propoxur, Red buckeye poisoning, Solvent abuse, Tranquilizer addiction
Dermatologic	Acne
Drug Side Effect	Acitretin, Agenerase, Aldomet, Amprenavir ,Anagrelide, Anastrozole, Arimidex, Atazanavir Sulfate, Atenolol, Cabergoline, Clopidogrel, Efavirenz, Efavirenz, Enfuvirtide, Etodolac, Exemestane, Felodipine, Flecainide, Galantamine, Goserelin, Guanabenz, Herceptin, Indomethacin, Klonopin, Labetalol, Lamictal, Lamivudine, Lamivudine, Levamisole, Levetiracetam, Raloxifene, Raloxifene, Rivastigmine, Stavudine, Tamoxifen, Temozolomide, Teriparatide, Tetrabenazine, Zolpidem,Zonisamide
Ear Nose Throat	No underlying causes
Endocrine	ACTH Deficiency, Addison's Disease, Adrenal hyperplasia, Alcohol-induced pseudo-Cushing syndrome, Andropause, Congenital adrenal hyperplasia (CAH), Cushing's disease, Cyclical edema syndrome, DiGeorge syndrome, Ectopic ACTH Syndrome, Hashimoto's Thyroiditis, Hyperparathyroidism, Hypopituitarism, Hypothyroidism, Lymphomatous thyroiditis, Myxedema, Post menstrual syndrome, Postpartum thyroiditis, Riedel syndrome, Wolfram's disease
Environmental	Decreased oxygen saturation
Gastroenterologic	Celiac Disease, Congenital hepatic porphyria, Short Bowel Syndrome
Genetic	22q11.2 deletion syndrome, Aceruloplasminemia, Chromosome 22q deletion, Kartagener syndrome, Turner Syndrome, Unverricht-Lundborg syndrome, Velocardiofacial syndrome, WAGR Syndrome, Young Simpson syndrome, Weinstein Kliman Scully syndrome
Hematologic	Megaloblastic anemia
Iatrogenic	No underlying causes
Infectious Disease	Acute Bokhoror, Cystitis, Borna disease, Chronic Hepatitis B, HIV, Human T-lymphotropic virus , Limbic encephalitis, Rabies
Musculoskeletal / Ortho	Myofascial pain syndromes, Osteoarthritis
Neurologic	Aging brain syndrome, Alzheimer's disease, Asperger syndrome, Autism, Baltic myoclonic epilepsy, Barre-Lieou syndrome, Basal ganglia calcification, Creutzfeldt-Jakob Disease, Dementia With Lewy Bodies, Frontal lobe dementia, Hepatic encephalopathy syndrome, Huntington's Disease, Neurosyphilis, Neurotoxicity syndromes, Niemann-Pick disease, PANDAS, Parkinson's Disease, Prion diseases, Pseudodementia, Sleep Apnea Syndromes, Westphal disease, Wilson's Disease
Nutritional / Metabolic	Acute intermittent porphyria, Anorexia Nervosa, Biotin deficiency, Burnett's milk drinker's syndrome, Decreased folate, Metabolic Syndrome, Pellagra, Porphyria, Pyridoxine deficiency, Uremic encephalopathy, Van Bogaert's disease, Variegate porphyria, Vitamin B12 Deficiency
Obstetric/Gynecologic	Cholestasis disease of pregnancy, Menopause
Oncologic	Adrenal adenoma, Adrenal Cancer, Breast Duct Papilloma, Functioning pancreatic endocrine tumor, Glucagonoma syndrome, Hip Tumor , Paraneoplastic limbic encephalitis, Pituitary tumors, Polycystic ovary syndrome, Rib Tumor
Opthalmologic	No underlying causes
Overdose / Toxicity	Pain killer addiction, Steroid abuse, Vitamin B6 toxicity
Psychiatric	ADD, ADHD, Bipolar disorder, Borderline Personality Disorder, Briquet syndrome, Burnout syndrome, Chronic Fatigue Syndrome, Cotard syndrome, Depressive disorders, Dysomnia, Dysthymia, Emotional disorders, Empty nest syndrome, Generalized anxiety disorder, Gulf War syndrome, Mood disorders, Neurosis, Nonaffective Psychosis, Nymphomania, Panic disorder, Personality disorder, Post partum depression, Post-traumatic stress disorder, Premenstrual dysphoric disorder, Psychosis, Schizophrenia, Situational depression, Social phobia, Vacinko syndrome
Pulmonary	Breathing-related sleep disorder, Obesity hypoventilation syndrome, Obsessive-compulsive disorder
Renal / Electrolyte	Phosphate diabetes, Wilms tumor
Rheum / Immune / Allergy	Autoimmune limbic encephalitis, Autoimmune thyroid diseases, Job syndrome, Kawasaki disease, Lupus, Polymyalgia rheumatica, Psoriasis, Systemic Lupus Erythematosus
Sexual	No underlying causes
Trauma	Traumatic Brain Injury
Urologic	No underlying causes
Dental	No underlying causes
Miscellaneous	Alcohol Withdrawal, Chat room addiction, Child abuse, Computer addiction, Moderate chronic pain, Online gambling addiction, Online shopping addiction, Stress

Causes in Alphabetical Order

• 22q11.2 deletion syndrome
• Aceruloplasminemia
• Acitretin
• Acne
• ACTH Deficiency
• Acute Bokhoror
• Acute intermittent porphyria
• Acute Pesticide poisoning
• ADD
• Addison's Disease
• ADHD
• Adrenal adenoma
• Adrenal Cancer
• Adrenal gland hypofunction
• Adrenal hyperplasia
• Agenerase
• Aging brain syndrome
• Alcohol Withdrawal
• Alcohol-induced pseudo-Cushing syndrome
• Aldomet
• Alzheimer's disease
• Amitrole
• Amphetamine
• Amprenavir
• Anagrelide
• Anastrozole
• Andropause
• Anorexia Nervosa
• Arimidex
• Asperger syndrome
• Atazanavir Sulfate
• Atenolol
• Autism
• Autoimmune limbic encephalitis
• Autoimmune thyroid diseases
• Baltic myoclonic epilepsy
• Barre-Lieou syndrome
• Basal ganglia calcification
• Basilar artery insufficiency
• Binswanger's Disease
• Biotin deficiency
• Bipolar disorder
• Black locust poisoning
• Borderline Personality Disorder
• Borna disease
• Bottlebrush buckeye poisoning
• Breast Duct Papilloma
• Breathing-related sleep disorder
• Briquet syndrome
• Burnett's milk drinker's syndrome
• Burnout syndrome
• Cabergoline
• California buckeye poisoning
• Celiac Disease
• Chat room addiction
• Child abuse
• Cholestasis disease of pregnancy
• Chromosome 22q deletion
• Chronic Fatigue Syndrome
• Chronic Hepatitis B
• Clopidogrel
• Coastal leucothoe poisoning
• Cocaine abuse
• Computer addiction
• Congenital adrenal hyperplasia (CAH)
• Congenital hepatic porphyria
• Cotard syndrome
• Crack addiction
• Creutzfeldt-Jakob Disease
• Cushing's disease
• Cycad nut poisoning
• Cyclical edema syndrome

• Cystitis
• Decreased folate
• Decreased oxygen saturation
• Dementia With Lewy Bodies
• Depressive disorders
• Dexedrine overdose
• DiGeorge syndrome
• Dysomnia
• Dysthymia
• Ecstasy
• Ectopic ACTH Syndrome
• Efavirenz
• Emotional disorders
• Empty nest syndrome
• Enfuvirtide
• Etodolac
• Exemestane
• Felodipine
• Fetterbush poisoning
• Flecainide
• Florida leucothoe poisoning
• Frontal lobe dementia
• Functioning pancreatic endocrine tumor
• Galantamine
• Generalized anxiety disorder
• Glucagonoma syndrome
• Goserelin
• Grayanotoxin
• Guanabenz
• Gulf War syndrome
• Hashimoto's Thyroiditis
• Hepatic encephalopathy syndrome
• Herceptin
• HipTumor
• HIV
• Human T-lymphotropic virus
• Huntington's Disease
• Hyperparathyroidism
• Hypopituitarism
• Hypothyroidism
• Indomethacin
• Inhalant abuse
• Job syndrome
• Kartagener syndrome
• Kawasaki disease
• Klonopin
• Labetalol
• Lamictal
• Lamivudine
• Lead poisoning
• Levamisole
• Levetiracetam
• Limbic encephalitis
• Lupus
• Lymphomatous thyroiditis
• Marijuana addiction
• Megaloblastic anemia
• Menopause
• Metabolic Syndrome
• Moderate chronic pain
• Mood disorders
• Myofascial pain syndromes
• Myxedema
• Neurosis
• Neurosyphilis
• Neurotoxicity syndromes
• Niemann-Pick disease
• Nonaffective Psychosis
• Nymphomania
• Obesity hypoventilation syndrome
• Obsessive-compulsive disorder
• Online gambling addiction

• Online shopping addiction
• Opioid addiction
• Osteoarthritis
• OxyContin withdrawal
• Pain killer addiction
• PANDAS
• Panic disorder
• Paraneoplastic limbic encephalitis
• Parkinson's Disease
• Pellagra
• Pernettya poisoning
• Personality disorder
• Phencyclidine
• Phosphate diabetes
• Pituitary tumors
• Polycystic ovary syndrome
• Polymyalgia rheumatica
• Porphyria
• Post menstrual syndrome
• Post partum depression
• Postpartum thyroiditis
• Post-traumatic stress disorder
• Premenstrual dysphoric disorder
• Prion diseases
• Propoxur
• Pseudodementia
• Psoriasis
• Psychosis
• Pyridoxine deficiency
• Rabies
• Raloxifene
• Red buckeye poisoning
• Rib Tumor
• Riedel syndrome
• Rivastigmine
• Schizophrenia
• Short Bowel Syndrome
• Situational depression
• Sleep Apnea Syndromes
• Social phobia
• Solvent abuse
• Stavudine
• Steroid abuse
• Stress
• Systemic Lupus Erythematosus
• Tamoxifen
• Temozolomide
• Teriparatide
• Tetrabenazine
• Tranquilizer addiction
• Traumatic Brain Injury
• Turner Syndrome
• Unverricht-Lundborg syndrome
• Uremic encephalopathy
• Vacinko syndrome
• Van Bogaert's disease
• Variegate porphyria
• Vascular malformations of the brain
• Velocardiofacial syndrome
• Vitamin B12 Deficiency
• Vitamin B6 toxicity
• WAGR Syndrome
• Weinstein Kliman Scully syndrome
• Westphal disease
• Wilms tumor
• Wilson's Disease
• Wolfram's disease
• Young Simpson syndrome
• Zolpidem
• Zonisamide

References