Obesity causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Causes

Common Causes

• Cushing's syndrome

• Drugs

• Diabetes

• Familial obesity

• Glucocorticoids

• Hypothyroidism

• Hyperandrogenism

• Metabolic Syndrome

• Overeating

• Physical inactivity

• Polycystic ovary syndrome

Causes by Organ System

Cardiovascular	Cardiomyopathy -- hypogonadism -- metabolic anomalies, Subaortic stenosis -- short stature syndrome, Hypogonadism -- mitral valve prolapse -- mental retardation, Obesity -- colitis -- hypothyroidism -- cardiac hypertrophy -- developmental delay complex
Chemical / poisoning	No underlying causes
Dermatologic	No underlying causes
Drug Side Effect	Amitriptyline, Cortisol, Imipramine, Citalopram, Chlorpromazine, Estrogen, Insulin, Gabapentin, Glitazones, Hormone replacement therapy , Lithium, Mirtazapine, Monoamine oxidase inhibitors (MAOIs), Olanzapine, Prednisolone, Prednisone, Paroxetine, Pizotifen, Propanolol, Sotalol, Sodium valproate, Sertraline, Sulphonylurea, Vigabatrin
Ear Nose Throat	Ayazi syndrome, Metaphyseal dysostosis - mental retardation - conductive deafness complex
Endocrine	Achard-Thiers Syndrome, Familial Adrenal adenoma, Adrenal incidentaloma, Aromatase deficiency, Borjeson Syndrome , Borjeson-Forssman-Lehmann syndrome , Bardet-Biedl syndrome, Cushing syndrome, Cushing's disease, Cardiomyopathy -- hypogonadism -- metabolic anomalies, Cortisone reductase deficiency, Diabetes, Functioning pancreatic endocrine tumor, HAIR-AN Syndrome, Hyperadrenalism, Hyperandrogenism, Hyperinsulinism, Hyperpituitarism, Hypogonadism -- mitral valve prolapse -- mental retardation complex, Hypogonadotropic -- hypogonadism -- syndactyly complex, Hydrocephalus-obesity-hypogonadism, Hypopituitaryism, Hypothyroidism, Insulinoma, Laurence-Moon-Biedl syndrome, Mauriac syndrome, Myxedema, Obesity -- colitis -- hypothyroidism -- cardiac hypertrophy -- developmental delay complex, Pseudohypoparathyroidism, Retinohepatoendocrinologic syndrome, Renal tubulopathy -- diabetes mellitus -- cerebellar ataxia complex, Schroeder syndrome 1, Sohval-Soffer syndrome
Environmental	No underlying causes
Gastroenterologic	Bearn-Kunkel syndrome, Obesity -- colitis -- hypothyroidism -- cardiac hypertrophy -- developmental delay complex, Retinohepatoendocrinologic syndrome
Genetic	Alstrom's Syndrome, Atkin-Flatiz syndrome, Bardet-Biedl syndrome, Biemond syndrome type 2, Carpenter syndrome, Chondrodysplasia, Grebe type, Chromosome 12p tetrasomy syndrome, Chromosome 1p deletion syndrome, Chromosome 21q deletion syndrome, Chromosome 3, trisomy 3q13 2 q25, Chromosome 4, trisomy 4p, Chromosome 5, trisomy 5q, Chromosome 5q duplication syndrome, Chromosome 9, partial trisomy 9p, Clark-Baraitser syndrome, Cohen syndrome, Congenital Leptin deficiency, Cortisone reductase deficiency, Duplication 5q, Fructose-1,6-bisphosphatase deficiency, Inherited predisposition, Klinefelter syndrome , Laron dwarfism, Laurence-Moon-Biedl syndrome, McCune-Albright Syndrome, Mental retardation X-linked short stature obesity, Mental retardation X-linked syndromic 7, Mental retardation, X linked -- precocious puberty -- obesity, Mental retardation, X-linked -- gynecomastia -- obesity complex, Mental retardation, X-linked -- hypogonadism -- ichthyosis -- obesity -- short stature complex, Mental retardation, X-linked, syndromic 11, MOMO syndrome, Partial deletion chromosome 11p, Partial duplication 9p , Prolidase deficiency, Schinzel Syndrome, Stewart-Morel-Morgagni Syndrome, Simpson-Golabi-Behmel syndrome, Summitt syndrome, Syndrome X, Urban rogers meyer syndrome, Vasquez Hurst Sotos syndrome, WAGR Syndrome, Williams Syndrome , Wilson-Turner X-linked mental retardation, X-linked mental retardation craniofacial abnormal microcepahly club, X-linked mental retardation-hypotonic facies syndrome, Young-Hughes syndrome
Hematologic	Bearn-Kunkel syndrome
Iatrogenic	No underlying causes
Infectious Disease	No underlying causes
Musculoskeletal / Ortho	Albright's hereditary osteodystrophy, Anophthalmia -- short stature -- obesity, Acrocephalopolysyndactyly - type 2 (ACPS 2), Bardet-Biedl syndrome, Biemond syndrome type 2, Cartilage Hair Hypoplasia, Carpenter syndrome, Chondrodysplasia, Grebe type, Clark-Baraitser syndrome, Cohen syndrome, Emerinopathy, Hyperostosis frontalis interna, Laurence-Moon-Biedl syndrome, McCune-Albright Syndrome, McKusick type metaphyseal chondrodysplasia, Metaphyseal dysostosis - mental retardation - conductive deafness complex, Overgrowth syndrome, type Fryer, Stewart-Morel-Morgagni Syndrome, Sohval-Soffer syndrome, Simpson-Golabi-Behmel syndrome
Neurologic	Acrocephalopolysyndactyly - type 2 (ACPS 2), Bobble-head doll syndrome, Borjeson Syndrome , Borjeson-Forssman-Lehmann syndrome , Chromophobe adenoma, Craniopharyngioma, Empty sella syndrome, Frohlich syndrome, Grahmann's syndrome, Growth Hormone Receptor Deficiency, Hyperpituitarism, Hydrocephalus-obesity-hypogonadism, Hypothalamic Dysfunction, Hypothalamus tumor, Increased intracranial pressure, Kleine-Levin-Critchley syndrome, Nguyen syndrome, Metaphyseal dysostosis - mental retardation - conductive deafness complex, Pituitary gland cancer, Polyneuropathy -- mental retardation -- acromicria -- premature menopause, Renal tubulopathy -- diabetes mellitus -- cerebellar ataxia complex, Third ventricle tumor
Nutritional / Metabolic	Abdominal obesity metabolic syndrome, Binge eating disorder, Cardiomyopathy -- hypogonadism -- metabolic anomalies, Fructose-1,6-bisphosphatase deficiency, Metabolic Syndrome, Nguyen syndrome
Obstetric/Gynecologic	OHSS, Polycystic ovary syndrome
Oncologic	Craniopharyngioma, Functioning pancreatic endocrine tumor, Pituitary gland cancer, Third ventricle tumor, WAGR Syndrome
Opthalmologic	Aniridia - ptosis - mental retardation - obesity familial type complex, Anophthalmia -- short stature -- obesity, Ayazi syndrome, Bardet-Biedl syndrome, Choroideremia, Laurence-Moon-Biedl syndrome, Retinohepatoendocrinologic syndrome, WAGR Syndrome
Overdose / Toxicity	No underlying causes
Psychiatric	Atkin-Flatiz syndrome, Borjeson Syndrome , Borjeson-Forssman-Lehmann syndrome , Biemond syndrome type 2, Clark-Baraitser syndrome, Cohen syndrome
Pulmonary	No underlying causes
Renal / Electrolyte	Renal tubulopathy -- diabetes mellitus -- cerebellar ataxia complex, WAGR Syndrome
Rheum / Immune / Allergy	Bearn-Kunkel syndrome
Sexual	No underlying causes
Trauma	No underlying causes
Urologic	No underlying causes
Dental	No underlying causes
Miscellaneous	Adiposogenital dystrophy, Albright like syndrome, Alcohol-induced pseudo-Cushing syndrome, Ampola syndrome, Familial obesity, Hypertrichosis-brachydactyly-obesity and mental retardation complex, Launois-Bensaude Syndrome, Leschke-Ullmann syndrome, Madelung's Disease, Menopause, Mental retardation -- blepharophimosis -- obesity -- web neck complex, Mental retardation -- epilepsy -- bulbous nose complex, Mental retardation -- epileptic seizures -- hypogonadism -- hypogenitalism -microcephaly -- obesity complex, Mental retardation -- gynecomastia -- obesity - X-linked , Mental retardation -- nasal hypoplasia -- obesity -- genital hypoplasia complex, Mental retardation - unusual facies ampola type , Multiple lipomas, Overeating , Physical inactivity, Polyphagia, Prader-Willi syndrome, Pubertal obesity, Sengers-Hamel-Otten syndrome, Weight cycling

Causes by Alphabetical Order

Abdominal obesity metabolic syndrome Achard-Thiers Syndrome Acrocephalopolysyndactyly - type 2(ACPS 2) Adiposogenital dystrophy Familial Adrenal adenoma Adrenal incidentaloma Albright like syndrome Albright's hereditary osteodystrophy Alcohol-induced pseudo-Cushing syndrome Alstrom's Syndrome Amitriptyline Ampola syndrome Aniridia - ptosis - mental retardation - obesity familial type complex Anophthalmia -- short stature -- obesity Aromatase deficiency Atkin-Flatiz syndrome Ayazi syndrome Bardet-Biedl syndrome Bearn-Kunkel syndrome Biemond syndrome type 2 Binge eating disorder Bobble-head doll syndrome Borjeson Syndrome Borjeson-Forssman-Lehmann syndrome Cardiomyopathy -- hypogonadism -- metabolic anomalies Carpenter syndrome Cartilage Hair Hypoplasia Chlorpromazine Chondrodysplasia, Grebe type Choroideremia Chromophobe adenoma Chromosome 12p tetrasomy syndrome Chromosome 1p deletion syndrome Chromosome 21q deletion syndrome Chromosome 3 - trisomy 3q13 2 q25 Chromosome 4 - trisomy 4p Chromosome 5 - trisomy 5q Chromosome 5q duplication syndrome Chromosome 9 - partial trisomy 9p Citalopram Clark-Baraitser syndrome Cohen syndrome Congenital leptin deficiency Cortisol Cortisone reductase deficiency Craniopharyngioma Cushing syndrome Cushing's disease Diabetes Duplication 5q Emerinopathy Empty sella syndrome Estrogen Familial obesity Frohlich syndrome Fructose-1,6-bisphosphatase deficiency Functioning pancreatic endocrine tumor Gabapentin Glitazones Grahmann's syndrome Growth Hormone Receptor Deficiency HAIR-AN Syndrome Hormone replacement therapy Hydrocephalus-obesity-hypogonadism Hyperadrenalism Hyperandrogenism Hyperinsulinism Hyperostosis frontalis interna Hyperpituitarism Hypertrichosis-brachydactyly-obesity and mental retardation complex Hypogonadism -- mitral valve prolapse -- mental retardation Hypogonadotropic -- hypogonadism -- syndactyly Hypopituitaryism Hypothalamic Dysfunction Hypothalamus tumor Hypothyroidism Imipramine Increased intracranial pressure Inherited predisposition Insulin

Insulinoma Kleine-Levin-Critchley syndrome Klinefelter syndrome Laron dwarfism Launois-Bensaude Syndrome Laurence-Moon-Biedl syndrome Leschke-Ullmann syndrome Lithium Madelung's Disease Mauriac syndrome McCune-Albright Syndrome McKusick type metaphyseal chondrodysplasia Menopause Mental retardation -- blepharophimosis -- obesity -- web neck complex Mental retardation -- epilepsy -- bulbous nose complex Mental retardation -- epileptic seizures -- hypogonadism -- hypogenitalism -microcephaly -- obesity complex Mental retardation -- gynecomastia -- obesity - X-linked Mental retardation -- nasal hypoplasia -- obesity -- genital hypoplasia complex Mental retardation - unusual facies ampola type Mental retardation X-linked short stature obesity Mental retardation X-linked syndromic 7 Mental retardation, X linked -- precocious puberty -- obesity Mental retardation, X-linked -- gynecomastia -- obesity complex Mental retardation, X-linked -- hypogonadism -- ichthyosis -- obesity -- short stature complex Mental retardation, X-linked, syndromic 11 Metabolic Syndrome Metaphyseal dysostosis - mental retardation - conductive deafness complex Mirtazapine MOMO syndrome Monoamine oxidase inhibitors (MAOIs) Multiple lipomas Myxedema Nguyen syndrome Obesity -- colitis -- hypothyroidism -- cardiac hypertrophy -- developmental delay complex OHSS Olanzapine Overeating Overgrowth syndrome, type Fryer Paroxetine Partial deletion chromosome 11p Partial duplication 9p Physical inactivity Pituitary gland cancer Pizotifen Polycystic ovary syndrome Polyneuropathy -- mental retardation -- acromicria -- premature menopause Polyphagia Prader-Willi syndrome Prednisolone Prednisone Prolidase deficiency Propanolol Pseudohypoparathyroidism Pubertal obesity Renal tubulopathy -- diabetes mellitus -- cerebellar ataxia complex Retinohepatoendocrinologic syndrome Schinzel Syndrome Schroeder syndrome 1 Sengers-Hamel-Otten syndrome Sertraline Simpson-Golabi-Behmel syndrome Sodium valproate Sohval-Soffer syndrome Sotalol Stein-Leventhal syndrome Stewart-Morel-Morgagni Syndrome Subaortic stenosis -- short stature syndrome Sulphonylurea Summitt syndrome Syndrome X Third ventricle tumor Urban rogers meyer syndrome Vasquez Hurst Sotos syndrome Vigabatrin WAGR Syndrome Weight cycling Williams Syndrome Wilson-Turner X-linked mental retardation X-linked mental retardation craniofacial abnormal microcepahly club X-linked mental retardation-hypotonic facies syndrome Young-Hughes syndrome