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==Other Diagnostic Studies== | ==Other Diagnostic Studies== | ||
*[[Manometry]], the key test for establishing the diagnosis. A probe measures the pressure waves in different parts of the esophagus and stomach during the act of swallowing. A thin tube is inserted through the nose, and the patient is instructed to swallow several times. | *'''[[Manometry]]''', the key test for establishing the diagnosis. A probe measures the pressure waves in different parts of the esophagus and stomach during the act of swallowing. A thin tube is inserted through the nose, and the patient is instructed to swallow several times. | ||
*:* Elevated resting LES pressure, usually > 45 mmHg. | *:* Elevated resting LES pressure, usually > 45 mmHg. | ||
*:* Incomplete relaxation of the LES. | *:* Incomplete relaxation of the LES. | ||
*:* Aperistalsis – contractions may be absent, diffuse and not coordinated, and / or ‘vigorous’ (> 60 mmHg). | *:* Aperistalsis – contractions may be absent, diffuse and not coordinated, and / or ‘vigorous’ (> 60 mmHg). | ||
* | * '''Cholecystokinin''' (CCK) stimulation test: CCK causes mild contraction of the LES and a more pronounced release of inhibitory neurotransmitters in the wall of the esophagus. In normal people, LES tone will decrease due to the predominant effect of the inhibitory neurotransmitters. In patients with achalasia, however, the stimulatory effect on the LES is unopposed, and LES pressure increases. | ||
*'''[[Endoscopy]]''', which provides a view inside the esophagus and stomach. A small camera is inserted through the mouth while the patient is under sedation. The endoscopist observes a "pop" as the scope passes through the non-relaxing [[lower esophageal sphincter]]. | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} |
Revision as of 17:01, 27 August 2012
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Other Diagnostic Studies
- Manometry, the key test for establishing the diagnosis. A probe measures the pressure waves in different parts of the esophagus and stomach during the act of swallowing. A thin tube is inserted through the nose, and the patient is instructed to swallow several times.
- Elevated resting LES pressure, usually > 45 mmHg.
- Incomplete relaxation of the LES.
- Aperistalsis – contractions may be absent, diffuse and not coordinated, and / or ‘vigorous’ (> 60 mmHg).
- Cholecystokinin (CCK) stimulation test: CCK causes mild contraction of the LES and a more pronounced release of inhibitory neurotransmitters in the wall of the esophagus. In normal people, LES tone will decrease due to the predominant effect of the inhibitory neurotransmitters. In patients with achalasia, however, the stimulatory effect on the LES is unopposed, and LES pressure increases.
- Endoscopy, which provides a view inside the esophagus and stomach. A small camera is inserted through the mouth while the patient is under sedation. The endoscopist observes a "pop" as the scope passes through the non-relaxing lower esophageal sphincter.