Pulmonary hypertension laboratory tests

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Assistant Editor(s)-in-Chief: Ralph Matar,

Laboratory Findings

• Biochemistry,hematology and Thyroid function tests are required in all patients with pulmonary hypertension.(Important for diagnosis of chronic hemolytic anemia,myeloproliferative disorders,thyroid disorders chronic renal failure on dialysis).
• Serologic testing to detect Connective tissue diseases(systemic sclerosis), HIV and Hepatitis.

Systemic sclerosis is very important to exclude in pulmonary hypertension because this systemic disease has a very high prevalence of pulmonary arterial hypertension.Anti-Scl-70, anti-centromere,and U3-RNP are typically positive.

• Liver function tests to exclude portal hypertension.
• Both ANP and BNP have been shown to correlate with the survival in Idiopathic Pulmonary Hypertension,However NT-proBNP appears to be an independant predictor of survival and correlates with RV dysfunction.
• Serum uric acid: reflects impaired oxidative metabolism of ischemic peripheral tissues..