Splenomegaly causes: Difference between revisions

Jump to navigation Jump to search
← Older editNewer edit →
VisualWikitext
Aditya Govindavarjhulla (talk | contribs)
nocaptcha
23,349 edits
Aditya Govindavarjhulla (talk | contribs)
nocaptcha
23,349 edits
Line 4: Line 4:
==Overview==
==Overview==
==Causes==
==Causes==
==Causes of Splenomegaly in Alphabetical Order==
===Causes of Splenomegaly in Alphabetical Order===


<ref>Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:77 ISBN 1591032016</ref> <ref>Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:68 ISBN 140510368X</ref>
<ref>Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:77 ISBN 1591032016</ref> <ref>Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:68 ISBN 140510368X</ref>
Line 121: Line 121:
*:* [[Toxoplasmosis]]
*:* [[Toxoplasmosis]]
*:* [[Typhoid fever]]
*:* [[Typhoid fever]]
===Differential diagnosis of causes by organ system or pathogenesis===
'''Splenomegaly grouped on the basis of the pathogenic mechanism'''
{| class="wikitable"
|-
! Increased function
! Abnormal blood flow
! Infitration
|-
| '''''Removal of defective RBCs'''''
[[Spherocytosis]]<br />
[[Thalassemia]]<br />
[[Hemoglobinopathies]]<br />
Nutritional [[anemia]]s<br />
early [[sickle cell anemia]]<br />
'''''Immune hyperplasia'''''<br />
''Response to infection (viral,bacterial,fungal,parasitic'')<br />[[Mononucleosis]], [[AIDS]], [[viral hepatitis]]<br />subacute [[bacterial endocarditis]], bacterial [[septicemia]]<br /> splenic [[abscess]], [[typhoid fever]]<br />[[brucellosis]],[[ leptospirosis]], [[tuberculosis]]<br />[[histoplasmosis]]<br />[[malaria]], [[leishmaniasis]], [[trypanosomiasis]]<br />[[ehrlichiosis]]<br />''Disordered immunoregulation''<br />[[Rheumatoid arthritis]]<br />[[SLE]]<br />[[Serum sickness]]<br />[[Autoimmune hemolytic anemia]]<br />[[Idiopathic thrombocytopenic purpura|Immune thrombocytopenia]]<br />[[sarcoidosis]]<br />drug reactions<br />'''''Extramedullary hematopoiesis'''''<br />[[Myelofibrosis]]<br />Marrow infiltration by [[tumors]], [[leukemias]]<br />marrow damage by [[radiation]], [[toxins]]
|'''''Organ Failure'''''<br />
[[Cirrhosis]]<br />[[congestive heart failure]]<br />'''''Vascular'''''<br />[[hepatic vein obstruction]]<br />[[Portal vein thrombosis|portal vein obstruction]]<br />[[Budd-Chiari syndrome]]<br />[[splenic vein obstruction]]<br />'''''Infections'''''<br /><br />hepatic [[schistosomiasis]]<br />hepatic [[echinococcosis]]
|'''''Metabolic diseases'''''<br />[[Gauchers disease]]<br />[[Niemann-Pick disease]]<br />[[Hurler syndrome]] and other [[Mucopolysaccharidoses]]<br />[[Amyloidosis]]<br />[[Tangier disease]]<br />'''''Benign and malignant infiltrations'''''<br />[[Leukemias]](acute,chronic,lymphoid and myeloid)<br />lymphomas([[Hodgkins]] and [[Non-Hodgkin lymphoma|non-hodgkins]])<br />[[myeloproliferative]] disorders<br />[[metastatic]] tumors(commonly [[melanoma]])<br />[[histiocytosis X]]<br />[[Hemangioma]],[[lymphangioma]]<br />splenic [[cysts]]<br />[[hamartomas]]<br />[[eosinophilic granuloma]]
|}
<br />
The causes of massive splenomegaly (>1000gms) are much fewer and include:<br /><br />[[Thalassemia]]<br />[[Kala-Azar]] ([[Leishmaniasis]])<br />[[Portal hypertension]] of Bilharziasis<br />[[Chronic myelogenous leukemia]]<br />[[lymphomas]]<br />[[hairy cell leukemia]]<br />[[myelofibrosis]]<br />[[polycythemia vera]]<br />[[Gauchers disease]]<br />[[chronic lymphocytic leukemia]]<br />[[sarcoidosis]]<br />[[autoimmune hemolytic anemia]]<br />[[Malaria]]


==References==
==References==

Revision as of 20:07, 29 August 2012

Template:Splenomegaly Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Causes

Causes of Splenomegaly in Alphabetical Order

[1] [2]

Differential diagnosis of causes by organ system or pathogenesis

Splenomegaly grouped on the basis of the pathogenic mechanism

Increased function Abnormal blood flow Infitration
Removal of defective RBCs

Spherocytosis
Thalassemia
Hemoglobinopathies
Nutritional anemias
early sickle cell anemia
Immune hyperplasia
Response to infection (viral,bacterial,fungal,parasitic)
Mononucleosis, AIDS, viral hepatitis
subacute bacterial endocarditis, bacterial septicemia
splenic abscess, typhoid fever
brucellosis,leptospirosis, tuberculosis
histoplasmosis
malaria, leishmaniasis, trypanosomiasis
ehrlichiosis
Disordered immunoregulation
Rheumatoid arthritis
SLE
Serum sickness
Autoimmune hemolytic anemia
Immune thrombocytopenia
sarcoidosis
drug reactions
Extramedullary hematopoiesis
Myelofibrosis
Marrow infiltration by tumors, leukemias
marrow damage by radiation, toxins

Organ Failure

Cirrhosis
congestive heart failure
Vascular
hepatic vein obstruction
portal vein obstruction
Budd-Chiari syndrome
splenic vein obstruction
Infections

hepatic schistosomiasis
hepatic echinococcosis

Metabolic diseases
Gauchers disease
Niemann-Pick disease
Hurler syndrome and other Mucopolysaccharidoses
Amyloidosis
Tangier disease
Benign and malignant infiltrations
Leukemias(acute,chronic,lymphoid and myeloid)
lymphomas(Hodgkins and non-hodgkins)
myeloproliferative disorders
metastatic tumors(commonly melanoma)
histiocytosis X
Hemangioma,lymphangioma
splenic cysts
hamartomas
eosinophilic granuloma


The causes of massive splenomegaly (>1000gms) are much fewer and include:

Thalassemia
Kala-Azar (Leishmaniasis)
Portal hypertension of Bilharziasis
Chronic myelogenous leukemia
lymphomas
hairy cell leukemia
myelofibrosis
polycythemia vera
Gauchers disease
chronic lymphocytic leukemia
sarcoidosis
autoimmune hemolytic anemia
Malaria

References

  1. ↑ Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:77 ISBN 1591032016
  2. ↑ Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:68 ISBN 140510368X
  3. ↑ Kahan, Scott, Smith, Ellen G. In a page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:157

Template:WH Template:WS

Retrieved from "https://www.wikidoc.org/index.php?title=Splenomegaly_causes&oldid=703411"