Thrombocytopenia causes: Difference between revisions
Jump to navigation
Jump to search
(Created page with "__NOTOC__ {{Thrombocytopenia}} Please help WikiDoc by adding content here. It's easy! Click here to learn about editing. {{CMG}} ==Overview== ...") |
No edit summary |
||
| Line 151: | Line 151: | ||
==Medication-induced== | ==Medication-induced== | ||
Thrombocytopenia associated with medications can be due to either a reduction in production of platelets or increased destruction. | Thrombocytopenia associated with medications can be due to either a reduction in production of platelets or increased destruction. | ||
=====List of potential etiologies:===== | |||
{{col-begin}} | |||
{{col-break}} | |||
[[Low molecular weight heparin]]s | |||
Sulphonamides | |||
Drugs, hormones and mediators | |||
[[5-Azacytidine]] | |||
[[Abciximab]] | |||
Aclarubicin | |||
[[Actinomycin D]] | |||
[[Aggrastat]] | |||
[[Albendazole]] | |||
[[Alemtuzumab]] | |||
[[Altretamine]] | |||
[[Amiodarone]] | |||
[[Amrinone]] | |||
[[Anagrelide]] | |||
Anazolene | |||
Antithymocyte globulin | |||
[[Ardeparin]] | |||
[[Arsenic]] trioxide | |||
[[Azathioprine]] | |||
[[Bendamustine]] | |||
[[Benoxaprofen]] | |||
[[Bortezomib]] | |||
[[Captopril]] | |||
[[Caspofungin]] | |||
[[Chloramphenicol]] | |||
[[Cilazapril]] | |||
[[Cimetidine]] | |||
[[Cladribine]] | |||
[[Clofarabine]] | |||
[[Dasatinib]] | |||
[[Decitabine]] | |||
[[Desferrioxamine]] | |||
[[Doxorubicin]] | |||
[[Efalizumab]] | |||
{{col-break}} | |||
[[Eflornithine]] | |||
[[Epirubicin]] | |||
[[Eptifibatide]] | |||
[[Ethanol]] | |||
[[Flucytosine]] | |||
[[Fondaparinux]] | |||
[[Ganciclovir]] | |||
[[Gemcitabine]] | |||
[[Gemtuzumab ozogamicin]] | |||
[[Gold salts]] | |||
Guanidinium | |||
Haem arginate | |||
[[Heparin]] | |||
[[Ibritumomab tiuxetan]] | |||
[[Idarubicin]] | |||
[[Imatinib mesylate]] | |||
[[Indomethacin]] | |||
[[Integrilin]] | |||
[[Interferon alpha]] | |||
[[Interleukin 10]] | |||
[[Interleukin 2]] | |||
[[Irinotecan]] | |||
[[Ixabepilone]] | |||
[[Lenalidomide]] | |||
[[Lomustine]] | |||
[[Melphalan]] | |||
[[Mercaptopurine]] | |||
[[Methyldopa]] | |||
Methyldopate | |||
[[Mithramycin]] | |||
[[Nelarabine]] | |||
[[Nilotinib]] | |||
{{col-break}} | |||
[[Nitisinone]] | |||
[[Oxaliplatin]] | |||
Para-amino [[salicylic acid]] | |||
[[Pemetrexed]] | |||
[[Penicillamine]] | |||
[[Pentamidine]] | |||
[[Phenylbutazone]] | |||
[[Pyrimethamine]] | |||
[[Quinidine]] | |||
[[Quinine]] | |||
[[Ranitidine]] | |||
[[ReoPro]] | |||
[[Rifampicin]] | |||
[[Sirolimus]] | |||
[[Sorafenib]] | |||
[[Stiripentol]] | |||
Sulphasalazine | |||
Sunitinib malate | |||
[[Temozolomide]] | |||
[[Ticlopidine]] | |||
[[Tirofiban]] | |||
[[Topotecan]] | |||
[[Trabectedin]] | |||
[[Trimetrexate]] | |||
[[Valganciclovir]] | |||
[[Valproic acid]] | |||
[[Vancomycin]] | |||
[[Vinorelbine]] | |||
[[Vorinostat]] | |||
|} | |||
===Epiphenomenon=== | |||
Kasabach-Merritt syndrome | |||
Paraneoplastic syndrome | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
[[Category:Needs content]] | [[Category:Needs content]] | ||
Revision as of 00:37, 30 August 2012
|
Thrombocytopenia Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Thrombocytopenia causes On the Web |
|
American Roentgen Ray Society Images of Thrombocytopenia causes |
|
Risk calculators and risk factors for Thrombocytopenia causes |
Please help WikiDoc by adding content here. It's easy! Click here to learn about editing.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Causes
There are two broad mechanisms of thrombocytopenia: reduced platelet production and increased platelet destruction. Thormbocytopenia is seen in a variety of infectious and genetic disorders as well as a side effect of a large list of phramacotherapies.
Decreased production
Vitamin deficiencies
- Vitamin B12 deficiency
- Folic acid deficiency
- Iron deficiency
Hematologic disorders
- Pancytopenia
- Aplastic anemia
- Acute lymphoblastic leukemia
- Acute myeloid leukemia
- Chronic lymphocytic leukaemia
- Chronic myeloid leukaemia
- Hairy cell leukaemia
- Myeloma
- Non-Hodgkin lymphoma
- Myelodysplastic syndrome
- Myelofibrosis
Reduced thrombopoiesis due to reduced thrombopoietin production
- Decreased production of thrombopoietin by the liver in liver failure.
Infectious etiologies
- Sepsis, systemic viral or bacterial infection
- Dengue fever can cause thrombocytopenia by direct infection of bone marrow megakaryocytes as well as immunological shortened platelet survival
- Protozoa and protozoal conditions
- Visceral leishmaniasis
- Human granulocytic ehrlichiosis
- Human monocytotropic ehrlichiosis
- Mycoplasma pneumonia
- Staphylococcal toxic shock syndrome
- Epstein-Barr virus
- Hantavirus
- HIV-1 disease
- Infectious mononucleosis
- Lassa fever
- Measles
- Mumps
- Oklahoma tick fever
- Rubella
- Severe acute respiratory distress syndrome
- Tick born encephalitis
Intrauterine acquired conditions
Hereditary syndromes
- Congenital Amegakaryocytic Thrombocytopenia (CAMT)
- Bernard-Soulier syndrome, associated with large platelets
- May-Hegglin anomaly, the combination of thrombocytopenia, pale-blue leuckocyte inclusions, and giant platelets
- Grey platelet syndrome
- Alport syndrome
Chromosomal abnormalities
Mendelian inherited conditions
- Autoimmune lymphoproliferative syndrome type 1
- Autoimmune lymphoproliferative syndrome type 2
- Radial aplasia-thrombocytopenia syndrome or Thrombocytopenia absent radius syndrome
- von Willebrand disease, platelet type
Autosomal dominant conditions
- Arias oculootoradial syndrome
- Complement factor H deficiency
- Fechtner syndrome
- May-Hegglin anomaly
- Platelet glycoprotein 4 deficiency
- Sebastian platelet syndrome
Autosomal recessive conditions
- Chediak-Higashi disease
- Dibasic aminoaciduria type 2
- Familial histiocytic reticulosis
- Fanconi anaemia
- Folate malabsorption hereditary
- Gaucher disease
- Griscelli syndrome type 1
- Histiocytosis X
- Holocarboxylase synthase deficiency
- Iminodipeptiduria
- Isovaleric acidaemia
- Methylmalonic aciduria type 2
- Neuroectodermal melanolysosomal disease
- Niemann-Pick disease type B
- Omenn syndrome
- Platelet glycoprotein Ib deficiency
- Propionyl-CoA carboxylase deficiency PCCA type
- Sea blue histiocytosis
- Shwachman-Diamond syndrome
X-linked inherited conditions
- GATA1-related cytopenia
- Immunodysregulation polyendocrinopathy and enteropathy, X-linked
- Wiskott-Aldrich syndrome
- X-linked hyperimmunoglobulin M syndrome
- Mitochondrial genome inherited conditions
- MELAS
Chemical exposure
- Strontium-89
- Zinc
Increased destruction
Hematologic Disorders
- Idiopathic thrombocytopenic purpura (ITP)
- Thrombotic thrombocytopenic purpura (TTP)
- Hemolytic-uremic syndrome (HUS)
- Disseminated intravascular coagulation (DIC)
- Paroxysmal nocturnal hemoglobinuria (PNH)
- Neonatal alloimmune thrombocytopenia (NAITP)
- Following transfusion or post transfusion alloimmune thrombocytopenia
- Evans syndrome
- Macrophage activation syndrome
Cardiovascular causes
- Cholesterol embolism
- Intraaortic balloon pump placement
- Endocarditis
Obstetric disorders
Autoimmunde Disorders
Infectious Disorders
- Dengue fever has been shown to cause shortened platelet survival and immunological platelet destruction
- HIV [2]
Other disorders
- Splenic sequestration of platelets due to hypersplenism
Medication-induced
Thrombocytopenia associated with medications can be due to either a reduction in production of platelets or increased destruction.
List of potential etiologies:
|
Sulphonamides Drugs, hormones and mediators Aclarubicin Anazolene Antithymocyte globulin Arsenic trioxide
|
Guanidinium Haem arginate Methyldopate
|
Para-amino salicylic acid Sulphasalazine Sunitinib malate |
Epiphenomenon
Kasabach-Merritt syndrome Paraneoplastic syndrome