Myelodysplastic syndrome

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Myelodysplastic syndrome
ICD-10	D46
ICD-9	238.7
ICD-O:	9980/0-9989/3
DiseasesDB	8604
MeSH	D009190

Myelodysplastic syndrome Microchapters
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Overview
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Myelodysplastic syndrome from other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications and Prognosis
Diagnosis
History and Symptoms
Physical Examination
Laboratory Findings
Electrocardiogram
Chest X Ray
Echocardiography and Ultrasound
CT
MRI
Other Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy
Surgery
Primary Prevention
Secondary Prevention
Cost-Effectiveness of Therapy
Future or Investigational Therapies
Case Studies
Case #1
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Risk calculators and risk factors for Myelodysplastic syndrome

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Diagnosis

History & Symptoms | Physical Examination | Staging | Lab Tests | Electrocardiogram | Chest X Ray | CT | MRI | Echocardiography or Ultrasound | Other Imaging Findings | Other Diagnostic Studies

Treatment

Medical Therapy | Surgery | Primary Prevention | Secondary Prevention

Related chapters

• Myelodysplastic syndrome genetics
• Myeloproliferative syndrome
• Acute myeloid leukemia
• Chloroma

Additional Readings

• Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DA, Gralnick HR, Sultan C. Proposals for the classification of the myelodysplastic syndromes. Br J Haematol 1982;51:189. PMID 6952920.
• Block M, Jacobson LO, Bethard WF. Preleukemic acute human leukemia. JAMA 1953;152:1018-28. PMID 13052490.
• Harris NL, Jaffe ES, Diebold J, Flandrin G, Muller-Hermelink HK, Vardiman J, Lister TA, Bloomfield CD. World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues: report of the Clinical Advisory Committee meeting-Airlie House, Virginia, November 1997. J Clin Oncol 1999;17:3835-49. PMID 10577857.
• Foucar, K Bone Marrow Pathology, 2nd Edition, ASCP Press. c 2001
• Greenberg, Peter L. (editor) "Myelodysplastic Syndromes: Clinical and Biological Advances" Cambridge University Press, New York 2006 ISBN 978-0521496681 ISBN 0521496683
• Steensma DP, Gibbons RJ, Higgs DR. "Acquired alpha-thalassemia in association with myelodysplastic syndrome and other hematologic malignancies." Blood 2005;105:443-452. PMID 15358626.
• List A, Dewald G, Bennett J, Giagnounidis A, Raza A, Feldman E, Powell B, Greenberg P, Thomas D, Store R, Reeder C, Wride K, Patin J, Schmidt M, Zeldis J, Knight R. "Lenalidomide in the Myelodysplastic Syndrome with Chromosome 5q Deletion." NEJM 2006;355(14):1456-1465. PMID 17021321.
• Fenaux P, Mufti GJ, Lindberg EH, Santini V, Finelli C, Giagounidis A, Schoch R, Gatterman N, Sanz G, List A, Gore SD, Seymour JF, Bennett JM, Byrd J, Backstrum J, Zimmerman JF, McKenzie D, Beach CL, Silverman LR. "Efficacy of Azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised open-label phase III study." Lancet Oncology 2009;10(3):223-232. PMID 19230772.

Resources

• Cancer Medicine. Online textbook. Chapter by Lewis R. Silverman on Myelodysplastic Syndrome.
• Myelodysplastic syndromes. Comprehensive article from MayoClinic.com.
• [2] Agent Orange and MDS, 100% service connected.

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