Vasculitis pathophysiology: Difference between revisions

Jump to navigation Jump to search
No edit summary
No edit summary
Line 30: Line 30:
|-valign="top"
|-valign="top"
| [[Image:Kidney petechia 1.jpg|thumb|Kidney: Petechiae: Gross natural color, an excellent example of flea bitten kidney case had necrotizing vasculitis]]
| [[Image:Kidney petechia 1.jpg|thumb|Kidney: Petechiae: Gross natural color, an excellent example of flea bitten kidney case had necrotizing vasculitis]]
| [[Image:Leucocytoclastic vasculitis 2.jpg|thumb|Skin:Leucocytolastic vasculitis; legs]]
| [[Image:Leucocytoclastic vasculitis 1.jpg|thumb|Skin:Leucocytolastic vasculitis; a close up view]]
| [[Image:Leucocytoclastic vasculitis pustular type.jpg|thumb|Leucocytoclastic vasculitis; pustular type]]
|}
<br clear="left"/>
 
{| align="left"
|-valign="top"
| [[Image:Skin vasculitis.jpg|thumb|Vasculitis: In this instance, the vasculitic skin lesions were secondary to Haemophilus endocarditis.]]
| [[Image:Skin vasculitis2.jpg|thumb|Vasculitis: In this instance, the vasculitic skin lesions were secondary to Haemophilus endocarditis.]]
| [[Image:Skin vasculitis4.jpg|thumb|Vasculitis: In this instance, idiopathic with palpable purpura.]]
|}
<br clear="left"/>
 
{| align="left"
|-valign="top"
| [[Image:skin_vasculitis6.jpg|thumb|Vasculitis: Palpable Purpura: Secondary to idiopathic leukocytoplastic vasculitis.]]
| [[Image:Skin_vasculitis7.jpg|thumb|Vasculitis: In this instance, idiopathic.]]
| [[Image:skin_vasculitis5.jpg|thumb|Vasculitis: In this instance, idiopathic with palpable purpura.]]
|}
|}
<br clear="left"/>
<br clear="left"/>
Line 57: Line 40:
| [[Image:Coronary artery vasculitis due to transplant rejection 1.jpg|thumb|Coronary artery: Transplant Rejection: Micro high mag H&E small muscular artery vasculitis ]]
| [[Image:Coronary artery vasculitis due to transplant rejection 1.jpg|thumb|Coronary artery: Transplant Rejection: Micro high mag H&E small muscular artery vasculitis ]]
| [[Image:Ricketsia vasculitis.jpg|thumb|Vasculitis, Rocky Mountain Spotted Fever, immunoperoxidase staining vessels for Rickettsia rickettsii]]
| [[Image:Ricketsia vasculitis.jpg|thumb|Vasculitis, Rocky Mountain Spotted Fever, immunoperoxidase staining vessels for Rickettsia rickettsii]]
| [[Image:Leucocytoclastic vasculitis 1.jpg|thumb|Skin:Leucocytolastic vasculitis; a close up view]]
|}
|}
<br clear="left"/>
<br clear="left"/>

Revision as of 12:17, 31 August 2012

Vasculitis

Overview

Classification

Large-sized vessel vasculitis
Takayasu's Arteritis
Temporal Arteritis
Medium-sized vessel vasculitis
Kawasaki's Disease
Polyarteritis Nodosa
Small-sized vessel vasculitis
Churg-Strauss Syndrome
Cutaneous leukocytoclastic vasculitis
Essential cryoglobulinemic vasculitis
Henoch-Schonlein Purpura
Microscopic polyangiitis
Wegener's Granulomatosis
Variable-sized vessel vasculitis
Sjogren syndrome
Cogan syndrome
Single organ vasculitis
Primary central nervous system angiitis

Causes

Differential Diagnosis

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor-In-Chief: M.Umer Tariq [2]

Overview

Pathophysiology

Large vessel vasculitis

Medium vessel vasculitis

  • Polyarteritis nodosa - Systemic necrotizing vasculitis and aneurysm formation affecting both medium and small arteries. If only small vessels are affected, it is called microscopic polyangiitis, although it is more associated with Wegener's granulomatosis than to classic PAN.
  • Wegener's granulomatosis - Systemic vasculitis of medium and small arteries, including venules and arterioles. Produces granulomatous inflammation of the respiratory tracts and necrotizing, pauci-immune glomerulonephritis. Most common cause of saddle nose deformity in USA (nose flattened due to destruction of nasal septum by granulomatous inflammation).
  • Kawasaki disease - Usually in children, it affects large, medium, and small vessels, prominently the coronary arteries. Associated with a mucocutaneous lymph node syndrome.
  • Isolated CNS vasculitis - Affects medium and small arteries over a diffuse CNS area, without symptomatic extracranial vessel involvement.

Small vessel vasculitis

Gross Pathology

Kidney: Petechiae: Gross natural color, an excellent example of flea bitten kidney case had necrotizing vasculitis
Skin:Leucocytolastic vasculitis; a close up view


Microscopic Pathology

Kidney: Transplant: Micro H&E high mag excellent example acute vasculitis due to rejection
Coronary artery: Transplant Rejection: Micro high mag H&E small muscular artery vasculitis
Vasculitis, Rocky Mountain Spotted Fever, immunoperoxidase staining vessels for Rickettsia rickettsii


References

Template:WH Template:WS