Allylprodine: Difference between revisions
Jump to navigation
Jump to search
m Bot: Automated text replacement (-{{SIB}} + & -{{EH}} + & -{{EJ}} + & -{{Editor Help}} + & -{{Editor Join}} +) |
m Robot: Automated text replacement (-{{WikiDoc Cardiology Network Infobox}} +, -<references /> +{{reflist|2}}, -{{reflist}} +{{reflist|2}}) |
||
| Line 37: | Line 37: | ||
== References == | == References == | ||
{{reflist|2}} | |||
Latest revision as of 14:16, 4 September 2012
| File:Allylprodine.svg | |
| Clinical data | |
|---|---|
| Synonyms | Allylprodine |
| Identifiers | |
| |
| CAS Number | |
| PubChem CID | |
| E number | {{#property:P628}} |
| ECHA InfoCard | {{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value). |
| Chemical and physical data | |
| Formula | C18H25NO2 |
| Molar mass | 287.397 g/mol |
Allylprodine is an opioid analgesic that is an analogue of prodine. It was developed in the 1970s during research into the related drug pethidine.
Allylprodine is more potent as an analgesic than other similar drugs such as α-prodine, due to the allyl group binding to an additional amino acid target in the binding site on the μ-opioid receptor. It is also stereoselective, with one isomer being much more active.[1][2]
Allylprodine produces similar effects to other opioids, such as analgesia and sedation, along with side effects such as nausea, itching, vomiting and respiratory depression which may be harmful or fatal.
References
- ↑ Portoghese PS, Shefter E. Stereochemical studies on medicinal agents. 19. X-ray crystal structures of two (+/-)-allylprodine diastereomers. The role of the allyl group in conferring high stereoselectivity and potency at analgetic receptors. Journal of Medicinal Chemistry. 1976 Jan;19(1):55-7.
- ↑ Portoghese PS, Alreja BD, Larson DL. Allylprodine analogues as receptor probes. Evidence that phenolic and nonphenolic ligands interact with different subsites on identical opioid receptors. Journal of Medicinal Chemistry. 1981 Jul;24(7):782-7.
Categories:
- Pages with script errors
- Pages with broken file links
- E number from Wikidata
- ECHA InfoCard ID from Wikidata
- Chemical articles with unknown parameter in Infobox drug
- Articles without EBI source
- Chemical pages without ChemSpiderID
- Chemical pages without DrugBank identifier
- Articles without KEGG source
- Articles without InChI source
- Articles without UNII source
- Drugs missing an ATC code
- Drugs with no legal status
- Articles containing unverified chemical infoboxes
- Opioids
- Pharmacology
- Drugs