C4A

Complement component 4A (Rodgers blood group)
PDB rendering based on 1hzf.
Identifiers
Symbols	C4A ; C4; C4A2; C4A3; C4A4; C4A6; C4B; C4S; CO4; CPAMD2; RG; C4A; C4A13; C4A91; C4B1; C4B12; C4B2; C4B3; C4B5; C4F; CH; CPAMD3
External IDs	Template:OMIM5 Template:MGI HomoloGene: 36030
Gene ontology Molecular function Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

WikiDoc Resources for C4A
Articles
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Evidence Based Medicine
Cochrane Collaboration on C4A Bandolier on C4A TRIP on C4A
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List of terms related to C4A

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Complement component 4A (Rodgers blood group), also known as C4A, is a human gene.

This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene.

See also

• Complement component 4

Further reading

• Hugli TE (1987). "Biochemistry and biology of anaphylatoxins". Complement. 3 (3): 111–27. PMID 3542363.
• Yu CY (1999). "Molecular genetics of the human MHC complement gene cluster". Exp. Clin. Immunogenet. 15 (4): 213–30. PMID 10072631.
• Anderson MJ, Milner CM, Cotton RG, Campbell RD (1992). "The coding sequence of the hemolytically inactive C4A6 allotype of human complement component C4 reveals that a single arginine to tryptophan substitution at beta-chain residue 458 is the likely cause of the defect". J. Immunol. 148 (9): 2795–802. PMID 1573268.CS1 maint: Multiple names: authors list (link)
• Hessing M, van 't Veer C, Hackeng TM; et al. (1990). "Importance of the alpha 3-fragment of complement C4 for the binding with C4b-binding protein". FEBS Lett. 271 (1–2): 131–6. PMID 1699796.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yu CY (1991). "The complete exon-intron structure of a human complement component C4A gene. DNA sequences, polymorphism, and linkage to the 21-hydroxylase gene". J. Immunol. 146 (3): 1057–66. PMID 1988494.
• Ghiso J, Saball E, Leoni J; et al. (1990). "Binding of cystatin C to C4: the importance of sense-antisense peptides in their interaction". Proc. Natl. Acad. Sci. U.S.A. 87 (4): 1288–91. PMID 2304899.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yu CY, Belt KT, Giles CM; et al. (1987). "Structural basis of the polymorphism of human complement components C4A and C4B: gene size, reactivity and antigenicity". EMBO J. 5 (11): 2873–81. PMID 2431902.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Speiser PW, White PC (1990). "Structure of the human RD gene: a highly conserved gene in the class III region of the major histocompatibility complex". DNA. 8 (10): 745–51. PMID 2612324.
• Palsdottir A, Fossdal R, Arnason A; et al. (1987). "Heterogeneity of human C4 gene size. A large intron (6.5 kb) is present in all C4A genes and some C4B genes". Immunogenetics. 25 (5): 299–304. PMID 2883116.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kishore N, Shah D, Skanes VM, Levine RP (1989). "The fluid-phase binding of human C4 and its genetic variants, C4A3 and C4B1, to immunoglobulins". Mol. Immunol. 25 (9): 811–9. PMID 3264881.CS1 maint: Multiple names: authors list (link)
• Chakravarti DN, Campbell RD, Porter RR (1988). "The chemical structure of the C4d fragment of the human complement component C4". Mol. Immunol. 24 (11): 1187–97. PMID 3696167.CS1 maint: Multiple names: authors list (link)
• Belt KT, Yu CY, Carroll MC, Porter RR (1985). "Polymorphism of human complement component C4". Immunogenetics. 21 (2): 173–80. PMID 3838531.CS1 maint: Multiple names: authors list (link)
• Hortin G, Sims H, Strauss AW (1986). "Identification of the site of sulfation of the fourth component of human complement". J. Biol. Chem. 261 (4): 1786–93. PMID 3944109.CS1 maint: Multiple names: authors list (link)
• Moon KE, Gorski JP, Hugli TE (1981). "Complete primary structure of human C4a anaphylatoxin". J. Biol. Chem. 256 (16): 8685–92. PMID 6167582.CS1 maint: Multiple names: authors list (link)
• Palsdottir A, Cross SJ, Edwards JH, Carroll MC (1984). "Correlation between a DNA restriction fragment length polymorphism and C4A6 protein". Nature. 306 (5943): 615–6. PMID 6316164.CS1 maint: Multiple names: authors list (link)
• Belt KT, Carroll MC, Porter RR (1984). "The structural basis of the multiple forms of human complement component C4". Cell. 36 (4): 907–14. PMID 6546707.CS1 maint: Multiple names: authors list (link)
• Carroll MC, Campbell RD, Bentley DR, Porter RR (1984). "A molecular map of the human major histocompatibility complex class III region linking complement genes C4, C2 and factor B.". Nature. 307 (5948): 237–41. PMID 6559257.CS1 maint: Multiple names: authors list (link)
• Carroll MC, Porter RR (1983). "Cloning of a human complement component C4 gene". Proc. Natl. Acad. Sci. U.S.A. 80 (1): 264–7. PMID 6572000.
• Whitehead AS, Goldberger G, Woods DE; et al. (1983). "Use of a cDNA clone for the fourth component of human complement (C4) for analysis of a genetic deficiency of C4 in guinea pig". Proc. Natl. Acad. Sci. U.S.A. 80 (17): 5387–91. PMID 6577433.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)