Feingold syndrome: Difference between revisions
m (Bot: Automated text replacement (-{{SIB}} + & -{{EJ}} + & -{{EH}} + & -{{Editor Join}} + & -{{Editor Help}} +)) |
m (Robot: Automated text replacement (-{{WikiDoc Cardiology Network Infobox}} +, -<references /> +{{reflist|2}}, -{{reflist}} +{{reflist|2}})) |
||
Line 36: | Line 36: | ||
==References== | ==References== | ||
<div class="references-small" style="-moz-column-count:2; column-count:2;"> | <div class="references-small" style="-moz-column-count:2; column-count:2;"> | ||
{{reflist|2}} | |||
</div> | </div> | ||
Latest revision as of 17:24, 4 September 2012
Feingold syndrome | |
OMIM | 164280 |
---|---|
DiseasesDB | 33706 |
WikiDoc Resources for Feingold syndrome |
Articles |
---|
Most recent articles on Feingold syndrome Most cited articles on Feingold syndrome |
Media |
Powerpoint slides on Feingold syndrome |
Evidence Based Medicine |
Cochrane Collaboration on Feingold syndrome |
Clinical Trials |
Ongoing Trials on Feingold syndrome at Clinical Trials.gov Trial results on Feingold syndrome Clinical Trials on Feingold syndrome at Google
|
Guidelines / Policies / Govt |
US National Guidelines Clearinghouse on Feingold syndrome NICE Guidance on Feingold syndrome
|
Books |
News |
Commentary |
Definitions |
Patient Resources / Community |
Patient resources on Feingold syndrome Discussion groups on Feingold syndrome Patient Handouts on Feingold syndrome Directions to Hospitals Treating Feingold syndrome Risk calculators and risk factors for Feingold syndrome
|
Healthcare Provider Resources |
Causes & Risk Factors for Feingold syndrome |
Continuing Medical Education (CME) |
International |
|
Business |
Experimental / Informatics |
Feingold syndrome (also called oculodigitoesophagoduodenal syndrome) is a rare autosomal dominant hereditary disorder. It is named after Murray Feingold, an American physician who first described the syndrome in 1975. Until 2003, at least 79 patients have been reported worldwide [1]
Characteristics
Feingold syndrome is marked by various combinations of microcephaly, limb malformations, esophageal and duodenal atresias, and sometimes learning disability or mental retardation[2].
Diagnosis and treatment
The diagnosis is based on the following clinical findings:
- microcephaly
- clinodactyly and shortness of index and little fingers
- syndactyly of 2nd & 3rd and 4th & 5th toe
- short palpebral fissures
- esophageal and/or duodenal atresia
Genetic etiology
![](/images/7/78/Autodominant2.jpg)
Feingold syndrome is caused by mutations in the neuroblastoma-derived V-myc avian myelocytomatosis viral-related oncogene (MYCN; OMIM 164840 [1]) which is located on the short arm of chromosome 2 (2p24.1).