HtrA serine peptidase 2: Difference between revisions
Jump to navigation
Jump to search
m Robot: Automated text replacement (-{{SIB}} + & -{{EH}} + & -{{EJ}} + & -{{Editor Help}} + & -{{Editor Join}} +) |
m Robot: Automated text replacement (-{{WikiDoc Cardiology Network Infobox}} +, -<references /> +{{reflist|2}}, -{{reflist}} +{{reflist|2}}) |
||
| Line 58: | Line 58: | ||
==References== | ==References== | ||
{{reflist}} | {{reflist|2}} | ||
==Further reading== | ==Further reading== | ||
{{refbegin | 2}} | {{refbegin | 2}} | ||
Revision as of 18:20, 4 September 2012
| HtrA serine peptidase 2 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 PDB rendering based on 1lcy. | |||||||||||||
| |||||||||||||
| Identifiers | |||||||||||||
| Symbols | HTRA2 ; OMI; PARK13; PRSS25 | ||||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 8300 | ||||||||||||
| |||||||||||||
| RNA expression pattern | |||||||||||||
 | |||||||||||||
 | |||||||||||||
| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Template:GNF Ortholog box | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | n/a | n/a | |||||||||||
| Ensembl | n/a | n/a | |||||||||||
| UniProt | n/a | n/a | |||||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||||
| RefSeq (protein) | n/a | n/a | |||||||||||
| Location (UCSC) | n/a | n/a | |||||||||||
| PubMed search | n/a | n/a | |||||||||||
HtrA serine peptidase 2, also known as HTRA2, is a human gene.[1]
This gene encodes a serine protease. The protein has been localized in the endoplasmic reticulum and interacts with an alternatively spliced form of mitogen-activated protein kinase 14. The protein has also been localized to the mitochondria with release to the cytosol following apoptotic stimulus. The protein is thought to induce apoptosis by binding the apoptosis inhibitory protein baculoviral IAP repeat-containing 4. Nuclear localization of this protein has also been observed. Alternate splicing of this gene results in two transcript variants encoding different isoforms. Additional transcript variants have been described, but their full-length sequences have not been determined.[1]
References
Further reading
- Zurawa-Janicka D, Narkiewicz J, Lipińska B (2007). "[Characterization of the HtrA family of proteins]". Postepy Biochem. 53 (1): 27–36. PMID 17718385.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.
- Faccio L, Fusco C, Chen A; et al. (2000). "Characterization of a novel human serine protease that has extensive homology to bacterial heat shock endoprotease HtrA and is regulated by kidney ischemia". J. Biol. Chem. 275 (4): 2581–8. PMID 10644717.
- Savopoulos JW, Carter PS, Turconi S; et al. (2000). "Expression, purification, and functional analysis of the human serine protease HtrA2". Protein Expr. Purif. 19 (2): 227–34. doi:10.1006/prep.2000.1240. PMID 10873535.
- Gray CW, Ward RV, Karran E; et al. (2000). "Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response". Eur. J. Biochem. 267 (18): 5699–710. PMID 10971580.
- Faccio L, Fusco C, Viel A, Zervos AS (2000). "Tissue-specific splicing of Omi stress-regulated endoprotease leads to an inactive protease with a modified PDZ motif". Genomics. 68 (3): 343–7. doi:10.1006/geno.2000.6263. PMID 10995577.
- Suzuki Y, Imai Y, Nakayama H; et al. (2001). "A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death". Mol. Cell. 8 (3): 613–21. PMID 11583623.
- Verhagen AM, Silke J, Ekert PG; et al. (2002). "HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins". J. Biol. Chem. 277 (1): 445–54. doi:10.1074/jbc.M109891200. PMID 11604410.
- Hegde R, Srinivasula SM, Zhang Z; et al. (2002). "Identification of Omi/HtrA2 as a mitochondrial apoptotic serine protease that disrupts inhibitor of apoptosis protein-caspase interaction". J. Biol. Chem. 277 (1): 432–8. doi:10.1074/jbc.M109721200. PMID 11606597.
- Vucic D, Deshayes K, Ackerly H; et al. (2002). "SMAC negatively regulates the anti-apoptotic activity of melanoma inhibitor of apoptosis (ML-IAP)". J. Biol. Chem. 277 (14): 12275–9. doi:10.1074/jbc.M112045200. PMID 11801603.
- van Loo G, van Gurp M, Depuydt B; et al. (2002). "The serine protease Omi/HtrA2 is released from mitochondria during apoptosis. Omi interacts with caspase-inhibitor XIAP and induces enhanced caspase activity". Cell Death Differ. 9 (1): 20–6. doi:10.1038/sj/cdd/4400970. PMID 11803371.
- Li W, Srinivasula SM, Chai J; et al. (2002). "Structural insights into the pro-apoptotic function of mitochondrial serine protease HtrA2/Omi". Nat. Struct. Biol. 9 (6): 436–41. doi:10.1038/nsb795. PMID 11967569.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Yang QH, Church-Hajduk R, Ren J; et al. (2003). "Omi/HtrA2 catalytic cleavage of inhibitor of apoptosis (IAP) irreversibly inactivates IAPs and facilitates caspase activity in apoptosis". Genes Dev. 17 (12): 1487–96. doi:10.1101/gad.1097903. PMID 12815069.
- Srinivasula SM, Gupta S, Datta P; et al. (2003). "Inhibitor of apoptosis proteins are substrates for the mitochondrial serine protease Omi/HtrA2". J. Biol. Chem. 278 (34): 31469–72. doi:10.1074/jbc.C300240200. PMID 12835328.
- Suzuki Y, Takahashi-Niki K, Akagi T; et al. (2004). "Mitochondrial protease Omi/HtrA2 enhances caspase activation through multiple pathways". Cell Death Differ. 11 (2): 208–16. doi:10.1038/sj.cdd.4401343. PMID 14605674.
- Okada M, Adachi S, Imai T; et al. (2004). "A novel mechanism for imatinib mesylate-induced cell death of BCR-ABL-positive human leukemic cells: caspase-independent, necrosis-like programmed cell death mediated by serine protease activity". Blood. 103 (6): 2299–307. doi:10.1182/blood-2003-05-1605. PMID 14645012.
- Park HJ, Seong YM, Choi JY; et al. (2004). "Alzheimer's disease-associated amyloid beta interacts with the human serine protease HtrA2/Omi". Neurosci. Lett. 357 (1): 63–7. doi:10.1016/j.neulet.2003.11.068. PMID 15036614.
- Guo Y, Cheong N, Zhang Z; et al. (2004). "Tim50, a component of the mitochondrial translocator, regulates mitochondrial integrity and cell death". J. Biol. Chem. 279 (23): 24813–25. doi:10.1074/jbc.M402049200. PMID 15044455.