LRRK2

Leucine-rich repeat kinase 2
Identifiers
Symbols	LRRK2 ; AURA17; PARK8; RIPK7; ROCO2
External IDs	Template:OMIM5 Template:MGI HomoloGene: 18982
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE LRRK2 gnf1h07577 s at tn.png
File:PBB GE LRRK2 gnf1h07580 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

LRRK2 is a protein member of the leucine-rich repeat kinase family.

The LRRK2 gene encodes a protein with an ankyrin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson's disease type 8.

Further reading

• Singleton AB (2005). "Altered alpha-synuclein homeostasis causing Parkinson's disease: the potential roles of dardarin". Trends Neurosci. 28 (8): 416–21. doi:10.1016/j.tins.2005.05.009. PMID 15955578.
• Mata IF, Wedemeyer WJ, Farrer MJ; et al. (2006). "LRRK2 in Parkinson's disease: protein domains and functional insights". Trends Neurosci. 29 (5): 286–93. doi:10.1016/j.tins.2006.03.006. PMID 16616379.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Haugarvoll K, Wszolek ZK (2006). "PARK8 LRRK2 parkinsonism". Current neurology and neuroscience reports. 6 (4): 287–94. PMID 16822348.
• Bonifati V (2006). "The pleomorphic pathology of inherited Parkinson's disease: lessons from LRRK2". Current neurology and neuroscience reports. 6 (5): 355–7. PMID 16928343.
• Schapira AH (2006). "The importance of LRRK2 mutations in Parkinson disease". Arch. Neurol. 63 (9): 1225–8. doi:10.1001/archneur.63.9.1225. PMID 16966498.
• Whaley NR, Uitti RJ, Dickson DW; et al. (2006). "Clinical and pathologic features of families with LRRK2-associated Parkinson's disease". J. Neural Transm. Suppl. (70): 221–9. PMID 17017533.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gasser T (2006). "Molecular genetic findings in LRRK2 American, Canadian and German families". J. Neural Transm. Suppl. (70): 231–4. PMID 17017534.
• Tan EK (2007). "Identification of a common genetic risk variant (LRRK2 Gly2385Arg) in Parkinson's disease". Ann. Acad. Med. Singap. 35 (11): 840–2. PMID 17160203.

External links

• LRRK2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)