Macrophage migration inhibitory factor

Macrophage migration inhibitory factor (glycosylation-inhibiting factor)
File:PBB Protein MIF image.jpg PDB rendering based on 1ca7.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1ca7​, 1cgq​, 1gcz​, 1gd0​, 1gif​, 1ljt​, 1mif​, 1p1g​, 2ooh​, 2oow​, 2ooz​
Identifiers
Symbols	MIF ; GIF; GLIF; MMIF
External IDs	Template:OMIM5 Template:MGI HomoloGene: 55655
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Macrophage migration inhibiting factor (MIF) is an inflammatory mediator associated with Rheumatoid Arthritis (RA) severity.

This gene encodes a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate an additional role in integrin signaling pathways.

Further reading

• Bucala R (1997). "MIF rediscovered: cytokine, pituitary hormone, and glucocorticoid-induced regulator of the immune response". FASEB J. 10 (14): 1607–13. PMID 9002552.
• Lolis E, Bucala R (2006). "Macrophage migration inhibitory factor". Expert Opin. Ther. Targets. 7 (2): 153–64. doi:10.1517/14728222.7.2.153. PMID 12667094.
• Calandra T, Roger T (2003). "Macrophage migration inhibitory factor: a regulator of innate immunity". Nat. Rev. Immunol. 3 (10): 791–800. doi:10.1038/nri1200. PMID 14502271.
• Shimizu T (2005). "Role of macrophage migration inhibitory factor (MIF) in the skin". J. Dermatol. Sci. 37 (2): 65–73. doi:10.1016/j.jdermsci.2004.08.007. PMID 15659324.
• Larson DF, Horak K (2006). "Macrophage migration inhibitory factor: controller of systemic inflammation". Critical care (London, England). 10 (2): 138. doi:10.1186/cc4899. PMID 16677407.