Cholestasis pathophysiology: Difference between revisions
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==Overview== | ==Overview== | ||
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Under a [[microscope]], the individual hepatocytes will have a brownish-green stippled appearance within the [[cytoplasm]], representing bile that cannot get out of the cell. Canalicular bile plugs between individual hepatocytes or within bile ducts may also be seen, representing bile that has been excreted from the hepatocytes but cannot go any further due to the obstruction. When these plugs occur within the bile duct, sufficient pressure (caused by bile accumulation) can cause them to rupture, spilling bile into the surrounding [[biological tissue|tissue]], causing hepatic [[necrosis]]. These areas are known as bile lakes, and are typically seen only with extra-hepatic obstruction. | Under a [[microscope]], the individual hepatocytes will have a brownish-green stippled appearance within the [[cytoplasm]], representing bile that cannot get out of the cell. Canalicular bile plugs between individual hepatocytes or within bile ducts may also be seen, representing bile that has been excreted from the hepatocytes but cannot go any further due to the obstruction. When these plugs occur within the bile duct, sufficient pressure (caused by bile accumulation) can cause them to rupture, spilling bile into the surrounding [[biological tissue|tissue]], causing hepatic [[necrosis]]. These areas are known as bile lakes, and are typically seen only with extra-hepatic obstruction. | ||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
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Revision as of 20:30, 5 September 2012
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
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Overview
Pathophysiology
Under a microscope, the individual hepatocytes will have a brownish-green stippled appearance within the cytoplasm, representing bile that cannot get out of the cell. Canalicular bile plugs between individual hepatocytes or within bile ducts may also be seen, representing bile that has been excreted from the hepatocytes but cannot go any further due to the obstruction. When these plugs occur within the bile duct, sufficient pressure (caused by bile accumulation) can cause them to rupture, spilling bile into the surrounding tissue, causing hepatic necrosis. These areas are known as bile lakes, and are typically seen only with extra-hepatic obstruction.