Piroxicam: Difference between revisions
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Revision as of 13:54, 6 September 2012
| File:Piroxicam.svg | |
| Clinical data | |
|---|---|
| Pregnancy category |
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| ATC code | |
| Pharmacokinetic data | |
| Metabolism | 4 to 10% renal |
| Elimination half-life | 30 to 86 hours |
| Excretion | 4 to 10% renal |
| Identifiers | |
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| CAS Number | |
| PubChem CID | |
| DrugBank | |
| E number | {{#property:P628}} |
| ECHA InfoCard | {{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value). |
| Chemical and physical data | |
| Formula | C15H13N3O4S |
| Molar mass | 331.348 g/mol |
Piroxicam (marketed in the U.S. under the trade name Feldene) is a non-steroidal anti-inflammatory drug used to relieve the symptoms of rheumatoid and osteoarthritis, primary dysmenorrhoea, postoperative pain; and act as an analgesic, especially where there is an inflammatory component. It is also used in veterinary medicine to treat certain neoplasias expressing cyclooxygenase (COX) receptors, such as bladder, colon, and prostate cancers.
Other brand names for Piroxicam include "Brexin," "Erazon," "Felden", "Feldoral," "Hotemin," "Pirox von ct," "Proponol," "Reumador," "Veral," and "Vurdon."
Mechanism of action
Piroxicam is an NSAID and, as such, is a non-selective COX inhibitor possessing both analgesic and antipyretic properties. It undergoes entero-hepatic circulation.
Adverse effects
Piroxicam use can result in gastrointestinal toxicity, tinnitus, dizziness, headache, rash, and pruritus. The most severe adverse reactions are peptic ulceration and gastrointestinal bleeding. Approximately 30% of all patients receiving daily doses of 20 mg of piroxicam experience side effects.[1]
Piroxicam may cause skin to become more sensitive to sunlight. Avoidance of sunlight and use of sunscreen is recommended.[citation needed]
Footnotes
- ↑ New Zealand Medicines and Medical Devices Safety Authority. "Candyl Medicines datasheet". Retrieved 2006-09-10.
Template:Topical products for joint and muscular pain de:Piroxicam he:פירוקסיקאם hu:Piroxicam
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- Non-steroidal anti-inflammatory drugs
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