Cirrhosis future or investigational therapies: Difference between revisions
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{{CMG}} {{AOEIC}} {{UJ}} | {{CMG}} {{AOEIC}} {{UJ}} | ||
==Overview== | ==Overview== | ||
Cirrhosis is a complication of liver disease, which result in irreversible [[scar|scarring]], and loss of [[hepatocytes]]. | Cirrhosis is a complication of liver disease, which result in irreversible [[scar|scarring]], and loss of [[hepatocytes]]. Cirrhosis has many etiologies but [[alcohol]] and [[viral]] [[Hepatitis B]] and [[Hepatitis C|C]] are the main causes of cirrhosis. | ||
Research is going on to determine the mechanism of scar formation and how to interrupt or reverse this process.<ref name="pmid12869458">{{cite journal| author=Iredale JP| title=Cirrhosis: new research provides a basis for rational and targeted treatments. | journal=BMJ | year= 2003 | volume= 327 | issue= 7407 | pages= 143-7 | pmid=12869458 | doi=10.1136/bmj.327.7407.143 | pmc=PMC1126509 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12869458 }} </ref> Newer therapies are being developed against viral causes of liver diseases. Like Hepatitis B vaccine, vaccines are currently under development for Hepatitis C. | Research is going on to determine the mechanism of scar formation and how to interrupt or reverse this process.<ref name="pmid12869458">{{cite journal| author=Iredale JP| title=Cirrhosis: new research provides a basis for rational and targeted treatments. | journal=BMJ | year= 2003 | volume= 327 | issue= 7407 | pages= 143-7 | pmid=12869458 | doi=10.1136/bmj.327.7407.143 | pmc=PMC1126509 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12869458 }} </ref> Newer therapies are being developed against viral causes of liver diseases. Like Hepatitis B vaccine, vaccines are currently under development for Hepatitis C. | ||
Revision as of 14:08, 7 September 2012
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-In-Chief: Ujjwal Rastogi, M.B.B.S. [2]
Overview
Cirrhosis is a complication of liver disease, which result in irreversible scarring, and loss of hepatocytes. Cirrhosis has many etiologies but alcohol and viral Hepatitis B and C are the main causes of cirrhosis.
Research is going on to determine the mechanism of scar formation and how to interrupt or reverse this process.[1] Newer therapies are being developed against viral causes of liver diseases. Like Hepatitis B vaccine, vaccines are currently under development for Hepatitis C.
Future or Investigational Therapies
The following therapies are under trial:
- Obeticholic acid (OCA) for patients with primary biliary cirrhosis.[2]
- Boehringer Ingelheim’s investigational direct-acting antiviral compounds: BI 201335 (protease inhibitor) plus BI 207127 (polymerase inhibitor) for the treatment of Hepatitis C induced Cirrhosis.[3]
Reference
- ↑ Iredale JP (2003). "Cirrhosis: new research provides a basis for rational and targeted treatments". BMJ. 327 (7407): 143–7. doi:10.1136/bmj.327.7407.143. PMC 1126509. PMID 12869458.
- ↑ Lindor KD (2011). "Farnesoid X receptor agonists for primary biliary cirrhosis". Curr Opin Gastroenterol. 27 (3): 285–8. doi:10.1097/MOG.0b013e32834452c8. PMID 21297469.
- ↑ Zeuzem S, Asselah T, Angus P, Zarski JP, Larrey D, Müllhaupt B; et al. (2011). "Efficacy of the protease inhibitor BI 201335, polymerase inhibitor BI 207127, and ribavirin in patients with chronic HCV infection". Gastroenterology. 141 (6): 2047–55, quiz e14. doi:10.1053/j.gastro.2011.08.051. PMID 21925126.