Cirrhosis differential diagnosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Aditya Govindavarjhulla, M.B.B.S. [2]

Differentiating Cirrhosis from other Diseases

Differentiating Cirrhosis from other Diseases Based on Ascitic Fluid

Ascites may be caused by portal hypertension due to cirrhosis of liver or due to other causes like malignancies etc.,

Ascitic fluid analysis should be done to broadly categorize the cause of ascites.

Ascites is broadly classified as two types based on the serum-ascites albumin gradient (SAAG):

• Transudate - SAAG > 1.1 g/dL (indicates the ascites is due to portal hypertension).
• Exudate - SAAG < 1.1 g/dL (indicates the ascites is due to non-portal hypertension etiology).

References

Condition	Differentiating Signs and Symptoms	Differentiating Tests
Constrictive pericarditis	Immediate onset caused by IgE binding to mast cells causing degranulation and release of histamine.	Urticaria, anaphylaxis, angioedema, bronchospasm.
Budd-Chiari Syndrome	Delayed onset reaction caused by IgG or IgM antibodies, directed at drug-hapten coated cells.	Thrombocytopenia, anemia, cytopenia.
Splenic vein thrombosis	Delayed in onset and caused by IgG immune complex formation and deposition, and complement activation.	Vasculitis, serum sickness, arthralgia, fever, rash.
Portal vein thrombosis	The presentation of drug molecules by major histocompatability complexes to T cells, causing the release of cytokines and other inflammatory mediators. Also associated with the activation of eosinophils, monocytes, and neutrophils.	rashes, organ tissue damage, contact sensitivity.
Schistosomiasis	The presentation of drug molecules by major histocompatability complexes to T cells, causing the release of cytokines and other inflammatory mediators. Also associated with the activation of eosinophils, monocytes, and neutrophils.	rashes, organ tissue damage, contact sensitivity.
Sarcoidosis	The presentation of drug molecules by major histocompatability complexes to T cells, causing the release of cytokines and other inflammatory mediators. Also associated with the activation of eosinophils, monocytes, and neutrophils.	rashes, organ tissue damage, contact sensitivity.
Inferior vena cava obstruction	The presentation of drug molecules by major histocompatability complexes to T cells, causing the release of cytokines and other inflammatory mediators. Also associated with the activation of eosinophils, monocytes, and neutrophils.	rashes, organ tissue damage, contact sensitivity.