Dysgerminoma: Difference between revisions
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{{Infobox disease | | |||
Name = Dysgerminoma | | |||
Image = Seminoma high mag.jpg| | | |||
Caption = [[Micrograph]] a [[seminoma]], a tumour that is [[histology|histologically]] indistinguishable from a '''dysgerminoma'''. [[H&E stain]]. | | |||
DiseasesDB = | | |||
ICD10 = | | |||
ICD9 = {{ICD9|183.0}} | | |||
ICDO = 9060/3 | | |||
OMIM = | | |||
MedlinePlus = | | |||
MeshID = D004407 | | |||
}} | |||
{{Dysgerminoma}} | |||
{{CMG}} | |||
==Overview== | |||
A '''dysgerminoma''' is a type of [[germ cell tumor]];<ref name="pmid17587461">{{cite journal |author=Behtash N, Karimi Zarchi M |title=Dysgerminoma in three patients with Swyer syndrome |journal=World J Surg Oncol |volume=5 |issue= 1|pages=71 |year=2007 |pmid=17587461 |pmc=1934908 |doi=10.1186/1477-7819-5-71 |url=http://www.wjso.com/content/5//71}}</ref> it usually is [[malignant]] and usually occurs in the [[ovary]]. | |||
A tumor of the identical [[histology]] but not occurring in the ovary may be described by an alternate name: [[seminoma]] in the [[testis]]<ref>{{DorlandsDict|three/000033062|dysgerminoma}}</ref> or [[germinoma]] in the [[central nervous system]] or other parts of the body. | |||
Dysgerminoma accounts for less than 1% of ovarian tumors overall. Dysgerminoma usually occurs in [[adolescence]] and early adult life; about 5% occur in pre-pubertal children. Dysgerminoma is extremely rare after age 50. Dysgerminoma occurs in both ovaries in 10% of patients and, in a further 10%, there is microscopic tumor in the other ovary. | |||
Abnormal [[gonad]]s (due to [[gonadal dysgenesis]] and [[androgen insensitivity syndrome]]) have a high risk<ref>Nelson Textbook of Pediatrics, 18th ed. Chapter 553. Question 11, Gynecologic Problems of Childhood</ref> of developing a dysgerminoma. Most dysgerminomas are associated with elevated serum [[lactic dehydrogenase]] (LDH), which is sometimes used as a [[tumor marker]]. | |||
==Presentation== | |||
They are exceptionally associated with hypercalcemia. On gross examination, dysgerminomas present with a smooth, [[bosselated]] (knobby) external surface, and is soft, fleshy and either cream-coloured, gray, pink or tan when cut. Microscopic examination typically reveals uniform cells that resemble primordial germ cells. Typically, the [[stroma (animal tissue)|stroma]] contains [[lymphocyte]]s and about 20% of patients have sarcoid-like [[granuloma]]s. | |||
[[Metastases]] are most often present in the [[lymph node]]s. | |||
==Treatment== | |||
Dysgerminomas, like other [[seminomatous]] germ cell tumors, are very sensitive to both [[chemotherapy]] and [[radiotherapy]]. For this reason, with treatment patients' chances of long term survival, even cure, is excellent. | |||
==References== | |||
{{reflist}} | |||
{{Germ cell tumors}} | |||
{{Genital neoplasia}} | |||
[[Category:Gynaecological neoplasia]] | |||
[[Category:Germ cell neoplasia]] | |||
{{oncology-stub}} | |||
[[de:Dysgerminom]] | |||
[[it:Disgerminoma]] | |||
Revision as of 14:55, 10 September 2012
| Dysgerminoma | |
| Classification and external resources | |
| File:Seminoma high mag.jpg | |
|---|---|
| Micrograph a seminoma, a tumour that is histologically indistinguishable from a dysgerminoma. H&E stain. | |
| ICD-9 | 183.0 |
| ICD-O: | 9060/3 |
| MeSH | D004407 |
Template:Dysgerminoma Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
A dysgerminoma is a type of germ cell tumor;[1] it usually is malignant and usually occurs in the ovary.
A tumor of the identical histology but not occurring in the ovary may be described by an alternate name: seminoma in the testis[2] or germinoma in the central nervous system or other parts of the body.
Dysgerminoma accounts for less than 1% of ovarian tumors overall. Dysgerminoma usually occurs in adolescence and early adult life; about 5% occur in pre-pubertal children. Dysgerminoma is extremely rare after age 50. Dysgerminoma occurs in both ovaries in 10% of patients and, in a further 10%, there is microscopic tumor in the other ovary.
Abnormal gonads (due to gonadal dysgenesis and androgen insensitivity syndrome) have a high risk[3] of developing a dysgerminoma. Most dysgerminomas are associated with elevated serum lactic dehydrogenase (LDH), which is sometimes used as a tumor marker.
Presentation
They are exceptionally associated with hypercalcemia. On gross examination, dysgerminomas present with a smooth, bosselated (knobby) external surface, and is soft, fleshy and either cream-coloured, gray, pink or tan when cut. Microscopic examination typically reveals uniform cells that resemble primordial germ cells. Typically, the stroma contains lymphocytes and about 20% of patients have sarcoid-like granulomas.
Metastases are most often present in the lymph nodes.
Treatment
Dysgerminomas, like other seminomatous germ cell tumors, are very sensitive to both chemotherapy and radiotherapy. For this reason, with treatment patients' chances of long term survival, even cure, is excellent.
References
- ↑ Behtash N, Karimi Zarchi M (2007). "Dysgerminoma in three patients with Swyer syndrome". World J Surg Oncol. 5 (1): 71. doi:10.1186/1477-7819-5-71. PMC 1934908. PMID 17587461.
- ↑ Template:DorlandsDict
- ↑ Nelson Textbook of Pediatrics, 18th ed. Chapter 553. Question 11, Gynecologic Problems of Childhood