Superficial spreading melanoma: Difference between revisions

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Revision as of 18:28, 10 September 2012

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

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-==Overview==
-'''Superficial spreading melanoma''' (SSM) is the most common form of cutaneous [[melanoma]] in Caucasians. The average age at diagnosis is in the fifth decade, and it tends to occur on sun-exposed skin, especially on the backs of males and lower limbs of females.
-Often, this disease evolves from a precursor lesion, usually a [[dysplastic nevus]].  Otherwise it arises in previously normal skin.  A prolonged radial growth phase, where the lesion remains thin, may eventually be followed by a vertical growth phase where the lesion becomes thick and nodular.  As the risk of spread varies with the thickness, early SSM is more frequently cured than late nodular melanoma.
-The microscopic hallmarks are:
-* Large melanocytic cells with nest formation along the dermo-epidermal junction.
-* Invasion of the upper epidermis in a [[pagetoid]] fashion (discohesive single cell growth).
-* The pattern of rete ridges is often effaced.
-* Invasion of the dermis by atypical, pleomorphic melanocytes
-* Absence of the 'maturation' typical of naevus cells
-* Mitoses
-Treatment is by excisional biopsy, [[wide local excision]] and possibly [[sentinel lymph node|sentinel node biopsy]].  Spread of disease to local lymph nodes or distant sites (typically brain, bone, skin and lung) marks a decidedly poor prognosis.
 ==External links==
 * [http://www.rcpa.edu.au/applications/DocumentLibraryManager2/upload/Melanoma.pdf Fact File from the Royal College of Pathologists of Australasia (pdf)]

Superficial spreading melanoma: Difference between revisions

Revision as of 18:28, 10 September 2012

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