Krukenberg tumor: Difference between revisions

@@ Line 15: / Line 15: @@
 {{Krukenberg tumor}}
 {{CMG}}
-==Overview==
+==[[Krukenberg tumor overview|Overview]]==
-A '''Krukenberg tumor''' classically refers to a secondary ovarian malignancy whose primary site arose in the gastrointestinal tract. Krukenberg tumors are often found in both ovaries. Microscopically, they are characterized by appearance of [[mucin]]-secreting signet-ring cells in the tissue of the ovary; when the primary tumor is discovered, the same signet-ring cells will be found.
-==Historical==
+==[[Krukenberg tumor historical perspective|Historical Perspective]]==
-The Krukenberg tumor is named after Friedrich Ernst Krukenberg (1871-1946), a German doctor who first described them as "fibrosarcoma ovarii mucocellulare carcinomatodes". A short biography of Krukenberg can be found at [http://www.whonamedit.com/doctor.cfm/620.html WhoNamedIt.com]
-==Etiology and Incidence==
+==[[Krukenberg tumor pathophysiology|Pathophysiology]]==
-Metastatic cancer of the ovary accounts for only about 5% of [[ovarian cancer]]; in the remainder, the ovary is the primary cancer site. Krukenberg tumors are the third most common metastatic ovarian cancer (after epithelial and germ-cell tumors) and make up 14% of these cancers. Unlike some forms of cancer, there is no racial bias. Krukenberg tumors are most commonly seen in middle-aged and elderly females, around or following the [[menopause]].
-==Symptoms==
+==[[Krukenberg tumor causes|Causes]]==
-Patients with Krukenberg tumor often come to the attention of their doctor when they present complaining of abdominal or pelvic pain, bloatedness, vaginal bleeding, a change in their menstrual habit or pain during intercourse. These symptoms are non-specific (i.e. they point to a range of problems other than cancer) and a diagnosis can only be made following [[Computed Tomography]] (CT) scans, [[laparotomy]] and/or a [[biopsy]] of the ovary.
-==Pathogenesis==
+==[[Krukenberg tumor differential diagnosis|Differentiang Krukenberg tumor from other Diseases]]==
-There is some debate over the exact mechanism of metastasis of the tumour cells from the stomach, appendix or colon to the ovaries; classically it was thought that direct seeding across the abdominal cavity accounted for the spread of this tumor, but recently some researchers have suggested that lymphatic (i.e. through the lymph nodes), or haematogenous (i.e. through the blood) spread is more likely, as most of these tumours are found on the inside of the ovaries. Proponents of this theory cite the fact that [[metastases]] are never found in the [[omentum]] (the fatty apron which envelops the organs of the abdomen and lies between the stomach and ovaries), and that the tumor cells are found within the ovary and not growing inwards.
-However, this remains a controversy, as cases in Hong Kong always showed omental spread and peritoneal seedlings in patients with Krukenberg tumours.
-Although a Krukenberg tumor is most commonly a metastasis from a [[gastric cancer]] (usually an [[adenocarcinoma]]), this is not always the case. Other tumours of the [[gastrointestinal tract]] (including, significantly, [[colon cancer]]) have been known to cause Krukenberg tumours, and recent case-reports of Krukenberg tumors originating from tumors of the tip of the appendix have appeared in the medical literature.
+==[[Krukenberg tumor epidemiology and demographics|Epidemiology and Demographics]]==
-==Treatment and Prognosis==
+==[[Krukenberg tumor risk factors|Risk Factors]]==
-Since the Krukenberg tumor is a secondary (metastatic) tumor, management of the tumor must involve finding and treating the primary cancer. In general, most cases of Krukenberg tumor have a poor prognosis and radical operation such as removal of the ovaries (and the colon or appendix if involved) can improve survival only in cases of solitary ovarian metastasis or local extended disease (i.e. the lesion is located only in the pelvis). Cancer [[chemotherapy]] and [[radiotherapy]] before surgery may be used to shrink the tumor and facilitate its removal.
-==External links==
+==[[Krukenberg tumor screening|Screening]]==
-* {{Chorus|00498}}
-* {{WhoNamedIt|synd|572}}
+==[[Krukenberg tumor natural history, complications and prognosis|Natural History, Complications and Prognosis]]==
+==Diagnosis==
+[[Krukenberg tumor history and symptoms|History & Symptoms]] | [[Krukenberg tumor physical examination|Physical Examination]] | [[Krukenberg tumor laboratory findings|Laboratory Findings]] | [[Krukenberg tumor electrocardiogram|Electrocardiogram]] | [[Krukenberg tumor chest x ray|Chest X Ray]] | [[Krukenberg tumor CT|CT]] | [[Krukenberg tumor MRI|MRI]] | [[Krukenberg tumor ultrasound|Ultrasound]] | [[Krukenberg tumor other imaging findings|Other Imaging Findings]] | [[Krukenberg tumor other diagnostic studies|Other Diagnostic Studies]]
+==Treatment==
+[[Krukenberg tumor medical therapy|Medical Therapy]] | [[Krukenberg tumor surgery|Surgery]] | [[Krukenberg tumor primary prevention|Primary Prevention]] | [[Krukenberg tumor secondary prevention|Secondary Prevention]] | [[Krukenberg tumor cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[Krukenberg tumor future or investigational therapies|Future or Investigational Therapies]]
+==Case Studies==
+[[Krukenberg tumor case study one|Case #1]]


Krukenberg tumor
Krukenberg tumor
ICD-10	C56
ICD-9	183
ICD-O:	8490/6
DiseasesDB	30081
MeSH	C04.557.470.200.025.415.410

Krukenberg tumor: Difference between revisions

Revision as of 18:21, 11 September 2012

Diagnosis

Treatment

Case Studies

Navigation menu