Phyllodes tumor: Difference between revisions
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{{Infobox_Disease | | {{Infobox_Disease | | ||
Name = Phyllodes tumor | | Name = Phyllodes tumor | | ||
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{{SI}} | {{SI}} | ||
{{CMG}} | {{CMG}} | ||
{{SK}} Phylloides tumor | |||
==Overview== | ==Overview== | ||
'''Phyllodes tumors''' (from [[Greek language|Greek]]: ''phullon'' leaf) | '''Phyllodes tumors''' (from [[Greek language|Greek]]: ''phullon'' leaf), are typically large, fast growing masses that form from the periductal [[stroma]] of the [[breast]]. They account for less than 1% of all breast [[Neoplasia|neoplasms]]. | ||
Phyllodes tumors are a [[fibroepithelial tumor]] composed of an epithelial and a cellular stromal component. They may be considered [[benign]], borderline, or [[malignant]] depending on histologic features including stromal cellularity, infiltration at the tumor's edge, and [[mitoses|mitotic activity]]. | ==Pathophysiology== | ||
Phyllodes tumors are a [[fibroepithelial tumor]] composed of an epithelial and a cellular stromal component. They may be considered [[benign]], borderline, or [[malignant]] (cystosarcoma phyllodes or cystosarcoma phylloides) depending on histologic features including stromal cellularity, infiltration at the tumor's edge, and [[mitoses|mitotic activity]]. | |||
Phyllodes tumors are considered to be on a spectrum of disease<ref>{{cite journal |author=Deen SA, McKee GT, Kissin MW |title=Differential cytologic features of fibroepithelial lesions of the breast |journal=Diagn. Cytopathol. |volume=20 |issue=2 |pages=53-6 |year=1999 |pmid=9951596 |doi=}}</ref> that consists of [[fibroadenoma]], fibroadenoma variant and benign phyllodes. Some would extend the spectrum to include malignant phyllodes tumors and frank [[sarcoma]]. | |||
==Differentiating Phyllodes tumor from other Diseases== | |||
Phyllodes tumor should be differentiated from: | |||
* [[Fibroadenoma]] | |||
== | ==Epidemiology and Demographics== | ||
===Age=== | |||
Occurrence is most common between the ages of 40 and 50, prior to the [[menopause]]. This is about 15 years older than the typical age of patients with [[fibroadenoma]], a condition with which Phyllodes tumors may be confused. | |||
== | ===Gender=== | ||
Phyllodes tumor is predominantly a tumor of adult women, with very few examples reported in adolescents. | |||
== | ==Treatment== | ||
===Surgery=== | |||
The common treatment for phyllodes is [[wide local excision]]. Most patients are cured with [[surgery]]; the risk of developing local recurrence or [[metastasis|metastases]] is related to the histologic grade, according to the above-named features. | |||
==References== | |||
{{Reflist|2}} | |||
{{Soft tissue tumors and sarcomas}} | {{Soft tissue tumors and sarcomas}} | ||
Revision as of 16:14, 12 September 2012
| Phyllodes tumor | |
| ICD-10 | C50, D24, D48.6 |
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| ICD-9 | 217 |
| ICD-O: | M9020 |
| DiseasesDB | 3396 |
| MeSH | D003557 |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Synonyms and keywords: Phylloides tumor
Overview
Phyllodes tumors (from Greek: phullon leaf), are typically large, fast growing masses that form from the periductal stroma of the breast. They account for less than 1% of all breast neoplasms.
Pathophysiology
Phyllodes tumors are a fibroepithelial tumor composed of an epithelial and a cellular stromal component. They may be considered benign, borderline, or malignant (cystosarcoma phyllodes or cystosarcoma phylloides) depending on histologic features including stromal cellularity, infiltration at the tumor's edge, and mitotic activity.
Phyllodes tumors are considered to be on a spectrum of disease[1] that consists of fibroadenoma, fibroadenoma variant and benign phyllodes. Some would extend the spectrum to include malignant phyllodes tumors and frank sarcoma.
Differentiating Phyllodes tumor from other Diseases
Phyllodes tumor should be differentiated from:
Epidemiology and Demographics
Age
Occurrence is most common between the ages of 40 and 50, prior to the menopause. This is about 15 years older than the typical age of patients with fibroadenoma, a condition with which Phyllodes tumors may be confused.
Gender
Phyllodes tumor is predominantly a tumor of adult women, with very few examples reported in adolescents.
Treatment
Surgery
The common treatment for phyllodes is wide local excision. Most patients are cured with surgery; the risk of developing local recurrence or metastases is related to the histologic grade, according to the above-named features.
References