Gastrointestinal stromal tumor causes: Difference between revisions
Varun Kumar (talk | contribs) (Created page with "{{Gastrointestinal stromal tumor}} {{CMG}} ==Genetic Causes== Although some families with hereditary GISTs have been described, most cases are sporadic. ...") |
No edit summary |
||
| Line 1: | Line 1: | ||
__NOTOC__ | |||
{{Gastrointestinal stromal tumor}} | {{Gastrointestinal stromal tumor}} | ||
Please help WikiDoc by adding content here. It's easy! Click [[Help:How_to_Edit_a_Page|here]] to learn about editing. | |||
{{CMG}} | {{CMG}} | ||
== | ==Overview== | ||
==Causes== | |||
Although some families with [[genetic disorder|hereditary]] GISTs have been described, most cases are sporadic. | Although some families with [[genetic disorder|hereditary]] GISTs have been described, most cases are sporadic. | ||
| Line 13: | Line 19: | ||
[[Category:Types of cancer]] | [[Category:Types of cancer]] | ||
[[Category:Oncology]] | [[Category:Oncology]] | ||
[[Category:Needs content]] | |||
[[Category:Disease]] | |||
{{WikiDoc Help Menu}} | {{WikiDoc Help Menu}} | ||
{{WikiDoc Sources}} | {{WikiDoc Sources}} | ||
Revision as of 18:48, 12 September 2012
|
Gastrointestinal stromal tumor Microchapters |
|
Differentiating Gastrointestinal stromal tumor from other Diseases |
|---|
|
Diagnosis |
|
Treatment |
|
Case Studies |
|
Gastrointestinal stromal tumor causes On the Web |
|
American Roentgen Ray Society Images of Gastrointestinal stromal tumor causes |
|
Directions to Hospitals Treating Gastrointestinal stromal tumor |
|
Risk calculators and risk factors for Gastrointestinal stromal tumor causes |
Please help WikiDoc by adding content here. It's easy! Click here to learn about editing.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Causes
Although some families with hereditary GISTs have been described, most cases are sporadic.
In GIST cells, the c-kit gene is mutated approximately 85% to 90% of the time. 35% of the GIST cells that do not have a mutated c-kit ("wild-type") do have a mutation in another gene, PDGFR-α (platelet derived growth factor receptor alpha), which is a related tyrosine kinase. Mutations in the exons 11, 9 and rarely 13 and 17 of the c-kit gene are known to occur in GIST. D816V point mutations in c-kit exon 17 are responsible for resistance to targeted therapy drugs like imatinib mesylate. Mutations in c-kit and PDGFrA are mutually exclusive[2][3].
References