Polycythemia vera case study one: Difference between revisions

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__NOTOC__
{{Gaucher's disease}}


{{CMG}}
==Case #1==
===Clinical Summary===
A 23-year-old black female delivered a stillborn infant by Caesarean section, following which she experienced excessive uterine bleeding including the passage of blood clots. Further study revealed an enlarged spleen and thrombocytopenia (platelet count 58,000). A splenectomy was performed with an uneventful postoperative course other than persistent pain in her right leg (the right hip had been fractured 2 years earlier). Subsequently she developed aseptic necrosis of the left femoral head requiring a prosthetic replacement. Microscopic evaluation of the bone removed at the time of surgery revealed Gaucher cells in the marrow space.
===Autopsy Findings===
The surgical specimen was a 935-gram spleen. Its surface was pale with an area of bluish discoloration. The cut surface revealed the same pale appearance.
===Histopathological Findings===
[http://www.peir.net Images courtesy of Professor Peter Anderson DVM PhD and published with permission © PEIR, University of Alabama at Birmingham, Department of Pathology]
{| align="center"
|-valign="top"
| [[Image:Gaucher disease 001.jpg|left|thumb|400px|This is a gross photograph of spleen from this case. The spleen is enlarged and the surface is finely granular. ]]
| [[Image:Gaucher disease 002.jpg|left|thumb|400px|This is a cut section of spleen from this case. Again note the fine granular appearance to the tissue. ]]
|}
{| align="center"
|-valign="top"
| [[Image:Gaucher disease 003.jpg|left|thumb|400px|This is a low-power photomicrograph of normal spleen (left) and the spleen from this case (right). The loose appearance of the tissue in the Gaucher spleen is due to artifactual loss of tissue during histologic processing. ]]
| [[Image:Gaucher disease 004.jpg|left|thumb|400px|This is a photomicrograph of the spleen from this case. There is very little if any white pulp evident in this section.]]
|}
{| align="center"
|-valign="top"
| [[Image:Gaucher disease 005.jpg|left|thumb|400px|This is a higher-power photomicrograph of the spleen from this case. Again there is no white pulp and the red pulp is filled with large eosinophilic cells.]]
| [[Image:Gaucher disease 006.jpg|left|thumb|400px|This is another high-power photomicrograph of the spleen from this case. At this power it is easier to see the large eosinophilic cells. ]]
|}
{| align="center"
|-valign="top"
| [[Image:Gaucher disease 007.jpg|left|thumb|400px|This is another high-power photomicrograph of the spleen from this case. At this high power individual cells can be better appreciated. ]]
| [[Image:Gaucher disease 008.jpg|left|thumb|400px|This is a higher-power photomicrograph of the spleen from this case. At this higher power individual cells can be better appreciated and the fibrillar nature of the eosinophilic cytoplasmic material can be seen. ]]
|}
==References==
{{Reflist|2}}
{{WH}}
{{WS}}

Revision as of 19:15, 12 September 2012