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Revision as of 13:23, 13 September 2012

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

A desmoid tumor (sometimes referred to as aggressive fibromatosis) is a rare (3 per million population) tumor that may or may not be part of a genetic syndrome such as familial adenomatous polyposis (FAP).

Classification

Desmoid tumors may be classified as extra-abdominal, abdominal wall, or intra-abdominal (the last is more common in patients with FAP). It is thought that the lesions may develop in relation to estrogen levels or trauma/operations.

Pathophysiology

Microscopic Pathology

Histologically, Desmoid tumors resemble low-grade fibrosarcomas, but they are very infiltrative and tend to recur even after complete resection (systemic metastasis is rare).

Treatment

Medical Therapy

Treatment may consist of watching and waiting, complete surgical removal, radiation therapy, antiestrogens and NSAIDs, or chemotherapy.

External links

Desmoid Tumor Research Foundation

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@@ Line 6: / Line 6: @@
 ==Overview==
+A '''desmoid tumor''' (sometimes referred to as ''aggressive fibromatosis'') is a rare (3 per million population) [[tumor]] that may or may not be part of a [[genetics|genetic]] [[syndrome]] such as [[familial adenomatous polyposis]] (FAP).
-A '''desmoid tumor''' (sometimes referred to as ''aggressive fibromatosis'') is a rare (3 per million population) [[tumor]] that may or may not be part of a [[genetics|genetic]] [[syndrome]] such as [[familial adenomatous polyposis]] (FAP).
+==Classification==
+Desmoid tumors may be classified as extra-[[human abdomen|abdominal]], [[layers of the abdominal wall|abdominal wall]], or intra-abdominal (the last is more common in patients with FAP). It is thought that the lesions may develop in relation to [[estrogen]] levels or [[physical trauma|trauma]]/[[surgery|operations]].
-Histologically they resemble [[grading (tumors)|low-grade]] [[fibrosarcoma]]s, but they are very [[infiltration (medicine)|infiltrative]] and tend to recur even after complete resection (systemic [[metastasis]] is rare).
+==Pathophysiology==
+===Microscopic Pathology===
-Desmoid tumors may be classified as extra-[[human abdomen|abdominal]], [[layers of the abdominal wall|abdominal wall]], or intra-abdominal (the last is more common in patients with FAP). It is thought that the lesions may develop in relation to [[estrogen]] levels or [[physical trauma|trauma]]/[[surgery|operations]].
+Histologically, Desmoid tumors resemble [[grading (tumors)|low-grade]] [[fibrosarcoma]]s, but they are very [[infiltration (medicine)|infiltrative]] and tend to recur even after complete resection (systemic [[metastasis]] is rare).
+==Treatment==
+===Medical Therapy===
 Treatment may consist of watching and waiting, complete [[surgery|surgical]] removal, [[radiation therapy]], [[antiestrogens]] and [[non-steroidal anti-inflammatory drug|NSAIDs]], or [[chemotherapy]].