Langerhans cell histiocytosis epidemiology and demographics: Difference between revisions
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==Overview== | |||
== Epidemiology == | == Epidemiology == | ||
LCH histiocytosis usually affects children of between 1 and 15 years old and peak incidence is between age 5 and 10. Among children under the age of 10, yearly incidence is thought to be 1 in 200,000<ref>{{cite web |url=http://www.nlm.nih.gov/medlineplus/ency/article/000068.htm |title=MedlinePlus Medical Encyclopedia: Histiocytosis |accessdate=2007-05-10 |format= |work=}}</ref>; and in adults even more rare, in about 1 in 560,000.<ref>{{cite web|url=http://www.histiocytosis.ca/facts.html | title=Histiocytosis Association of Canada | accessdate=2007-05-16|format= |work=}}</ref> It has been reported in elderly but is vanishingly rare<ref>{{cite journal |author=Gerlach B, Stein A, Fischer R, Wozel G, Dittert D, Richter G |title=[Langerhans cell histiocytosis in the elderly] |language=German |journal=Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete |volume=49 |issue=1 |pages=23-30 |year=1998 |pmid=9522189}}</ref>. commoner in white race and boys are effected twice as often as girls. | LCH histiocytosis usually affects children of between 1 and 15 years old and peak incidence is between age 5 and 10. Among children under the age of 10, yearly incidence is thought to be 1 in 200,000<ref>{{cite web |url=http://www.nlm.nih.gov/medlineplus/ency/article/000068.htm |title=MedlinePlus Medical Encyclopedia: Histiocytosis |accessdate=2007-05-10 |format= |work=}}</ref>; and in adults even more rare, in about 1 in 560,000.<ref>{{cite web|url=http://www.histiocytosis.ca/facts.html | title=Histiocytosis Association of Canada | accessdate=2007-05-16|format= |work=}}</ref> It has been reported in elderly but is vanishingly rare<ref>{{cite journal |author=Gerlach B, Stein A, Fischer R, Wozel G, Dittert D, Richter G |title=[Langerhans cell histiocytosis in the elderly] |language=German |journal=Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete |volume=49 |issue=1 |pages=23-30 |year=1998 |pmid=9522189}}</ref>. commoner in white race and boys are effected twice as often as girls. | ||
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Overview
Epidemiology
LCH histiocytosis usually affects children of between 1 and 15 years old and peak incidence is between age 5 and 10. Among children under the age of 10, yearly incidence is thought to be 1 in 200,000[1]; and in adults even more rare, in about 1 in 560,000.[2] It has been reported in elderly but is vanishingly rare[3]. commoner in white race and boys are effected twice as often as girls.
LCH is usually sporadic and non-hereditary condition but familial clustering has been noted in limited number of cases. Hashimoto-Pritzker disease, a variant of Hand-Schüller-Christian disease, is a congenital self-healing form[4].
References
- ↑ "MedlinePlus Medical Encyclopedia: Histiocytosis". Retrieved 2007-05-10.
- ↑ "Histiocytosis Association of Canada". Retrieved 2007-05-16.
- ↑ Gerlach B, Stein A, Fischer R, Wozel G, Dittert D, Richter G (1998). "[Langerhans cell histiocytosis in the elderly]". Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete (in German). 49 (1): 23–30. PMID 9522189.
- ↑ Kapur P, Erickson C, Rakheja D, Carder K, Hoang M (2007). "Congenital self-healing reticulohistiocytosis (Hashimoto-Pritzker disease): ten-year experience at Dallas Children's Medical Center". J. Am. Acad. Dermatol. 56 (2): 290–4. PMID 17224372.