Metastasis overview: Difference between revisions
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==Overview== | ==Overview== | ||
'''Metastasis''' (Greek: ''displacement, μετά=next + στάσις=placement'', plural: ''metastases''), sometimes abbreviated '''mets''', is the spread of a [[disease]] from one [[Organ (anatomy)|organ]] or part to another non-adjacent organ or part. Only [[cancer|malignant]] [[tumor cell]]s and infections have the capacity to '''metastasize'''. | |||
[[Cancer cell]]s can "break away", "leak", or "spill" from a [[primary tumor]], enter [[lymphatic vessel|lymphatic]] and [[blood vessel]]s, circulate through the bloodstream, and settle down to grow within normal tissues elsewhere in the body. Metastasis is one of three hallmarks of [[cancer|malignancy]] (contrast [[benign tumor]]s).<ref name="Robbins"> Kumar, Abbas, Fausto; ''Robbins and Cotran: Pathologic Basis of Disease''; Elsevier, 7th ed.</ref> Most [[tumor]]s and other [[neoplasia|neoplasms]] can metastasize, although in varying degrees, barring a few exceptions (e.g., [[Glioma]] and [[Basal cell carcinoma]] never metastasize).<ref name="Robbins"/> | |||
When tumor cells metastasize, the new tumor is called a ''secondary'' or ''metastatic'' tumor, and its cells are like those in the original tumor. This means, for example, that, if [[breast cancer]] spreads (metastasizes) to the lung, the secondary tumor is made up of abnormal breast cells, not of abnormal lung cells. The tumor in the lung is then called ''metastatic breast cancer'', not ''lung cancer''. | |||
[[Image:Secondary tumor deposits in the liver from a primary cancer of the pancreas.jpg|thumb|200px|center|Cut surface of a [[liver]] showing multiple metastatic nodules originating from [[pancreatic cancer]].]] | |||
==References== | ==References== | ||
Revision as of 16:58, 14 September 2012
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Metastasis (Greek: displacement, μετά=next + στάσις=placement, plural: metastases), sometimes abbreviated mets, is the spread of a disease from one organ or part to another non-adjacent organ or part. Only malignant tumor cells and infections have the capacity to metastasize.
Cancer cells can "break away", "leak", or "spill" from a primary tumor, enter lymphatic and blood vessels, circulate through the bloodstream, and settle down to grow within normal tissues elsewhere in the body. Metastasis is one of three hallmarks of malignancy (contrast benign tumors).[1] Most tumors and other neoplasms can metastasize, although in varying degrees, barring a few exceptions (e.g., Glioma and Basal cell carcinoma never metastasize).[1]
When tumor cells metastasize, the new tumor is called a secondary or metastatic tumor, and its cells are like those in the original tumor. This means, for example, that, if breast cancer spreads (metastasizes) to the lung, the secondary tumor is made up of abnormal breast cells, not of abnormal lung cells. The tumor in the lung is then called metastatic breast cancer, not lung cancer.
