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{{Glucagonoma}} | {{Glucagonoma}} | ||
{{CMG}} | {{CMG}} | ||
==Overview== | |||
== | ==Medical Therapy== | ||
Heightened glucagon secretion can be treated with the administration of [[Somatostatin|octreotide, a somatostatin analog]], which inhibits the release of glucagon.<ref>{{cite journal |author=Moattari AR, Cho K, Vinik AI |title=Somatostatin analogue in treatment of coexisting glucagonoma and pancreatic pseudocyst: dissociation of responses |journal=Surgery |volume=108 |issue=3 |pages=581-7 |year=1990 |pmid=2168587 |doi=}}</ref> | * Heightened glucagon secretion can be treated with the administration of [[Somatostatin|octreotide, a somatostatin analog]], which inhibits the release of glucagon.<ref>{{cite journal |author=Moattari AR, Cho K, Vinik AI |title=Somatostatin analogue in treatment of coexisting glucagonoma and pancreatic pseudocyst: dissociation of responses |journal=Surgery |volume=108 |issue=3 |pages=581-7 |year=1990 |pmid=2168587 |doi=}}</ref> | ||
The only curative therapy for glucagonoma is [[surgery|surgical]] resection, where the tumor is removed. Resection has been known to reverse symptoms in some patients. | * [[Doxorubicin]] and [[streptozotocin]] have also been used successfully to selectively damage alpha cells of the pancreatic islets. These do not destroy the tumor, but help to minimize progression of symptoms. | ||
* The only curative therapy for glucagonoma is [[surgery|surgical]] resection, where the tumor is removed. Resection has been known to reverse symptoms in some patients. | |||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
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[[Category:Types of cancer]] | [[Category:Types of cancer]] | ||
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[[Category:Oncology]] | [[Category:Oncology]] | ||
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Revision as of 18:01, 14 September 2012
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Medical Therapy
- Heightened glucagon secretion can be treated with the administration of octreotide, a somatostatin analog, which inhibits the release of glucagon.[1]
- Doxorubicin and streptozotocin have also been used successfully to selectively damage alpha cells of the pancreatic islets. These do not destroy the tumor, but help to minimize progression of symptoms.
- The only curative therapy for glucagonoma is surgical resection, where the tumor is removed. Resection has been known to reverse symptoms in some patients.