Fibrosarcoma: Difference between revisions
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==Overview== | ==Overview== | ||
'''Fibrosarcoma''' (fibroblastic sarcoma) is a [[malignant]] [[tumor]] derived from fibrous connective tissue and characterized by immature proliferating [[fibroblasts]] or undifferentiated [[anaplastic]] spindle cells. | '''Fibrosarcoma''' (fibroblastic sarcoma) is a [[malignant]] [[tumor]] derived from fibrous connective tissue and characterized by immature proliferating [[fibroblasts]] or undifferentiated [[anaplastic]] spindle cells. | ||
== | == Pathophysiology == | ||
The tumor may present different degrees of [[differentiation]]: low grade (differentiated), intermediate malignancy and high malignancy (anaplastic). Depending on this differentiation, tumor cells may resemble mature fibroblasts (spindle-shaped), secreting [[collagen]], with rare mitoses. These cells are arranged in short fascicles which split and merge, giving the appearance of "fish bone". Poorly differentiated tumors consist in more atypical cells, pleomorphic, giant cells, multinucleated, numerous atypical mitoses and reduced collagen production. Presence of immature blood vessels (sarcomatous vessels lacking endothelial cells) favors the bloodstream metastasizing. | The tumor may present different degrees of [[differentiation]]: low grade (differentiated), intermediate malignancy and high malignancy (anaplastic). Depending on this differentiation, tumor cells may resemble mature fibroblasts (spindle-shaped), secreting [[collagen]], with rare [[mitoses]]. These cells are arranged in short [[fascicles]] which split and merge, giving the appearance of "fish bone". Poorly differentiated tumors consist in more atypical cells, [[pleomorphic]], giant cells, [[multinucleated]], numerous atypical mitoses and reduced collagen production. Presence of immature blood vessels ([[sarcomatous]] vessels lacking [[endothelial]] cells) favors the bloodstream metastasizing. | ||
==See also== | ==See also== | ||
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==References== | ==References== | ||
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{{Soft tissue tumors and sarcomas}} | {{Soft tissue tumors and sarcomas}} | ||
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[[Category:Oncology]] | [[Category:Oncology]] | ||
[[Category:Types of cancer]] | [[Category:Types of cancer]] | ||
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Revision as of 18:23, 17 September 2012
| Fibrosarcoma | |
| ICD-O: | 8810/3 |
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| MeSH | D005354 |
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WikiDoc Resources for Fibrosarcoma |
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Most recent articles on Fibrosarcoma Most cited articles on Fibrosarcoma |
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Powerpoint slides on Fibrosarcoma |
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Evidence Based Medicine |
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Clinical Trials |
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Ongoing Trials on Fibrosarcoma at Clinical Trials.gov Clinical Trials on Fibrosarcoma at Google
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US National Guidelines Clearinghouse on Fibrosarcoma
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Definitions |
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Patient resources on Fibrosarcoma Discussion groups on Fibrosarcoma Patient Handouts on Fibrosarcoma Directions to Hospitals Treating Fibrosarcoma Risk calculators and risk factors for Fibrosarcoma
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Healthcare Provider Resources |
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Causes & Risk Factors for Fibrosarcoma |
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Continuing Medical Education (CME) |
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Experimental / Informatics |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
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Overview
Fibrosarcoma (fibroblastic sarcoma) is a malignant tumor derived from fibrous connective tissue and characterized by immature proliferating fibroblasts or undifferentiated anaplastic spindle cells.
Pathophysiology
The tumor may present different degrees of differentiation: low grade (differentiated), intermediate malignancy and high malignancy (anaplastic). Depending on this differentiation, tumor cells may resemble mature fibroblasts (spindle-shaped), secreting collagen, with rare mitoses. These cells are arranged in short fascicles which split and merge, giving the appearance of "fish bone". Poorly differentiated tumors consist in more atypical cells, pleomorphic, giant cells, multinucleated, numerous atypical mitoses and reduced collagen production. Presence of immature blood vessels (sarcomatous vessels lacking endothelial cells) favors the bloodstream metastasizing.
See also
References