Splenic marginal zone lymphoma pathophysiology: Difference between revisions
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==Overview== | ==Overview== | ||
== Pathophysiology == | |||
'''Splenic marginal zone lymphoma''' (SMZL) is a [[lymphoma]] comprised of [[B-cells]] that replace the normal architecture of the [[white pulp]] of the [[spleen]]. The neoplastic cells are both small [[lymphocytes]] and larger, transformed blasts, and they invade the mantle zone of [[splenic]] [[follicle]]s and erode the [[marginal zone]], ultimately invading the red pulp of the spleen. Frequently, the bone marrow and [[splenic]] [[hilar]] [[lymph nodes]] are involved along with the peripheral [[blood]]. The neoplastic cells circulating in the peripheral blood are termed villious lymphocytes due to their characteristic appearance.<ref name="who1">[http://www.iarc.fr/WHO-BlueBooks/BBwebsite/bb3.html] Jaffe E.S., Harris N.L., Stein H., Vardiman J.W. (eds): '''World Health Organization Classification of Tumors. Pathology and Genetics of Tumours of Haemopoietic and Lymphoid Tissues.''' IARC Press: Lyon 2001 </ref> | '''Splenic marginal zone lymphoma''' (SMZL) is a [[lymphoma]] comprised of [[B-cells]] that replace the normal architecture of the [[white pulp]] of the [[spleen]]. The neoplastic cells are both small [[lymphocytes]] and larger, transformed blasts, and they invade the mantle zone of [[splenic]] [[follicle]]s and erode the [[marginal zone]], ultimately invading the red pulp of the spleen. Frequently, the bone marrow and [[splenic]] [[hilar]] [[lymph nodes]] are involved along with the peripheral [[blood]]. The neoplastic cells circulating in the peripheral blood are termed villious lymphocytes due to their characteristic appearance.<ref name="who1">[http://www.iarc.fr/WHO-BlueBooks/BBwebsite/bb3.html] Jaffe E.S., Harris N.L., Stein H., Vardiman J.W. (eds): '''World Health Organization Classification of Tumors. Pathology and Genetics of Tumours of Haemopoietic and Lymphoid Tissues.''' IARC Press: Lyon 2001 </ref> | ||
==References== | ==References== | ||
Revision as of 15:22, 18 September 2012
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Splenic marginal zone lymphoma Microchapters |
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Differentiating Splenic marginal zone lymphoma from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [2]
Overview
Pathophysiology
Splenic marginal zone lymphoma (SMZL) is a lymphoma comprised of B-cells that replace the normal architecture of the white pulp of the spleen. The neoplastic cells are both small lymphocytes and larger, transformed blasts, and they invade the mantle zone of splenic follicles and erode the marginal zone, ultimately invading the red pulp of the spleen. Frequently, the bone marrow and splenic hilar lymph nodes are involved along with the peripheral blood. The neoplastic cells circulating in the peripheral blood are termed villious lymphocytes due to their characteristic appearance.[1]