Iron deficiency anemia pathophysiology: Difference between revisions
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* The main regulatory mechanism is situated in the gastrointestinal tract. | * The main regulatory mechanism is situated in the gastrointestinal tract. | ||
* When loss of iron is not sufficiently compensated by adequate intake after some time that is determined by the state of body iron storage, iron deficiency develops. | * When loss of iron is not sufficiently compensated by adequate intake after some time that is determined by the state of body iron storage, iron deficiency develops. | ||
==References== | ==References== |
Revision as of 15:28, 18 September 2012
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Physiology
- In the human body, iron is present in all cells and has several vital functions such as:
- A carrier of oxygen to the tissues from the lungs in the form of hemoglobin (Hb)
- Facilitator of oxygen use and storage in the muscles as myoglobin
- Transport medium for electrons within the cells in the form of cytochromes
- Integral part of enzyme reactions in various tissues.
- Total body iron averages approximately 3.8 g in men and 2.3 g in women.
Pathophysiology
- There are several mechanisms that control human iron metabolism and safeguard against iron deficiency.
- The main regulatory mechanism is situated in the gastrointestinal tract.
- When loss of iron is not sufficiently compensated by adequate intake after some time that is determined by the state of body iron storage, iron deficiency develops.