Whipple's triad: Difference between revisions
m Robot: Automated text replacement (-{{SIB}} +, -{{EH}} +, -{{EJ}} +, -{{Editor Help}} +, -{{Editor Join}} +) |
No edit summary |
||
| Line 1: | Line 1: | ||
__NOTOC__ | |||
{{SI}} | {{SI}} | ||
{{CMG}} | |||
{{SK}} Whipple's criteria; | |||
==Overview== | |||
'''Whipple's triad''' is a medical term which refers to three conditions that are considered by physicians necessary for proving [[hypoglycemia]] as the cause of a person's [[symptom]]s. They are stated in various versions, but the essential conditions are: | |||
#Symptoms known or likely to be caused by hypoglycemia | #Symptoms known or likely to be caused by hypoglycemia | ||
#A low glucose measured at the time of the symptoms | #A low glucose measured at the time of the symptoms | ||
Latest revision as of 01:26, 19 September 2012
|
WikiDoc Resources for Whipple's triad |
|
Articles |
|---|
|
Most recent articles on Whipple's triad Most cited articles on Whipple's triad |
|
Media |
|
Powerpoint slides on Whipple's triad |
|
Evidence Based Medicine |
|
Clinical Trials |
|
Ongoing Trials on Whipple's triad at Clinical Trials.gov Trial results on Whipple's triad Clinical Trials on Whipple's triad at Google
|
|
Guidelines / Policies / Govt |
|
US National Guidelines Clearinghouse on Whipple's triad NICE Guidance on Whipple's triad
|
|
Books |
|
News |
|
Commentary |
|
Definitions |
|
Patient Resources / Community |
|
Patient resources on Whipple's triad Discussion groups on Whipple's triad Patient Handouts on Whipple's triad Directions to Hospitals Treating Whipple's triad Risk calculators and risk factors for Whipple's triad
|
|
Healthcare Provider Resources |
|
Causes & Risk Factors for Whipple's triad |
|
Continuing Medical Education (CME) |
|
International |
|
|
|
Business |
|
Experimental / Informatics |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Synonyms and keywords: Whipple's criteria;
Overview
Whipple's triad is a medical term which refers to three conditions that are considered by physicians necessary for proving hypoglycemia as the cause of a person's symptoms. They are stated in various versions, but the essential conditions are:
- Symptoms known or likely to be caused by hypoglycemia
- A low glucose measured at the time of the symptoms
- Relief of symptoms when the glucose is raised to normal
History
The criteria date back to the 1930s, when it had been discovered that a few patients with hypoglycemic symptoms (such as shakiness, syncope or sweating) due to hypoglycemia could be cured by surgery to remove an insulinoma. However, it had also become apparent that a large proportion of people with symptoms suggestive of hypoglycemia had no need of surgery. Diagnostic testing was rudimentary: beyond a crude assay for reducing substances as an indirect measure of blood glucose, there was no way to measure hormones and metabolites such as insulin, and no imaging procedures for internal organs such as the pancreas.
Allen O. Whipple was a well-known surgeon who had pioneered pancreatic surgery. In an article entitled "The surgical therapy of hyperinsulinism", in J Internat Chir 3:237-276 (1938), he proposed that no pancreatic surgery to look for an insulinoma be performed unless these criteria were met.
Current use of the triad
The use and significance of the criteria have evolved over the last century as our understanding of the many forms of hypoglycemia has increased and our diagnostic tests and imaging procedures have improved. Whipple's criteria are no longer used to justify surgical exploration for an insulinoma, but to separate "true hypoglycemia" in which a low glucose can be demonstrated from a variety of other conditions (e.g., idiopathic postprandial syndrome) in which symptoms suggestive of hypoglycemia occur but low glucose levels cannot be demonstrated. The criteria are now invoked far more often by endocrinologists than by surgeons. The reliability of the criteria for this purpose has been a subject of contention among physicians.
In Popular Culture
Elliot in the tv series Scrubs was unable to name Whipple's Triad in the episode "My Balancing Act".