Insulin resistance overview: Difference between revisions
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==Overview== | ==Overview== | ||
'''Insulin resistance''' is the condition in which normal amounts of [[insulin]] are inadequate to produce a normal insulin response from [[fat]], [[muscle]] and [[liver]] [[cell (biology)|cells]]. Insulin resistance in fat cells results in [[hydrolysis]] of stored [[triglyceride]]s, which elevates free [[fatty acid]]s in the [[blood plasma]]. Insulin resistance in muscle reduces [[glucose]] uptake whereas insulin resistance in liver reduces glucose storage, with both effects serving to elevate blood glucose. High plasma levels of insulin and glucose due to insulin resistance often lead to [[metabolic syndrome]] and [[diabetes mellitus type 2|type 2 diabetes]]. | '''Insulin resistance''' is the condition in which normal amounts of [[insulin]] are inadequate to produce a normal insulin response from [[fat]], [[muscle]] and [[liver]] [[cell (biology)|cells]]. Insulin resistance in fat cells results in [[hydrolysis]] of stored [[triglyceride]]s, which elevates free [[fatty acid]]s in the [[blood plasma]]. Insulin resistance in muscle reduces [[glucose]] uptake whereas insulin resistance in liver reduces glucose storage, with both effects serving to elevate blood glucose. High plasma levels of insulin and glucose due to insulin resistance often lead to [[metabolic syndrome]] and [[diabetes mellitus type 2|type 2 diabetes]]. | ||
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[[Category:Disease]] | |||
[[Category:Endocrinology]] | |||
Revision as of 14:23, 19 September 2012
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Insulin resistance is the condition in which normal amounts of insulin are inadequate to produce a normal insulin response from fat, muscle and liver cells. Insulin resistance in fat cells results in hydrolysis of stored triglycerides, which elevates free fatty acids in the blood plasma. Insulin resistance in muscle reduces glucose uptake whereas insulin resistance in liver reduces glucose storage, with both effects serving to elevate blood glucose. High plasma levels of insulin and glucose due to insulin resistance often lead to metabolic syndrome and type 2 diabetes.