Laron syndrome historical perspective: Difference between revisions
Created page with "__NOTOC__ {{Laron syndrome}} ==Overview== ==References== {{reflist|2}} {{WH}} {{WS}} Category:Disease Category:Endocrinology" |
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{{Laron syndrome}} | {{Laron syndrome}} | ||
==Overview== | ==Overview== | ||
==Historical perspective== | |||
It is named after Zvi Laron, the Israeli researcher who, with A. Pertzelan and S. Mannheimer, first reported the condition in 1966<ref>{{WhoNamedIt|synd|2825}}</ref><ref name="pmid5916640">{{cite journal |author=Laron Z, Pertzelan A, Mannheimer S |title=Genetic pituitary dwarfism with high serum concentation of growth hormone--a new inborn error of metabolism? |journal=Isr. J. Med. Sci. |volume=2 |issue=2 |pages=152-5 |year=1966 |pmid=5916640 |doi=}}</ref>, based upon observations which began in 1958.<ref name="pmid15001582">{{cite journal |author=Laron Z |title=Laron syndrome (primary growth hormone resistance or insensitivity): the personal experience 1958-2003 |journal=J. Clin. Endocrinol. Metab. |volume=89 |issue=3 |pages=1031-44 |year=2004 |pmid=15001582 |doi=}}</ref> | |||
Resistance to [[GH]] was first reported by Laron in 1966. Since then, severe resistance to [[GH]], characterized by grossly impaired growth despite normal levels of [[GH]] in serum, has been termed Laron syndrome. | |||
===Homo floresiensis=== | |||
Recent publications have proposed that [[Homo floresiensis]] represented a population with widespread Laron syndrome.<ref name="pmid17596857">{{cite journal |author=Hershkovitz I, Kornreich L, Laron Z |title=Comparative skeletal features between Homo floresiensis and patients with primary growth hormone insensitivity (Laron syndrome) |journal=Am. J. Phys. Anthropol. |volume=134 |issue=2 |pages=198-208 |year=2007 |pmid=17596857 |doi=10.1002/ajpa.20655}}</ref><ref name="pmid17690271">{{cite journal |author=Culotta E |title=Paleoanthropology. The fellowship of the hobbit |journal=Science |volume=317 |issue=5839 |pages=740-2 |year=2007 |pmid=17690271 |doi=10.1126/science.317.5839.740}}</ref> | |||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
Revision as of 19:53, 19 September 2012
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Overview
Historical perspective
It is named after Zvi Laron, the Israeli researcher who, with A. Pertzelan and S. Mannheimer, first reported the condition in 1966[1][2], based upon observations which began in 1958.[3]
Resistance to GH was first reported by Laron in 1966. Since then, severe resistance to GH, characterized by grossly impaired growth despite normal levels of GH in serum, has been termed Laron syndrome.
Homo floresiensis
Recent publications have proposed that Homo floresiensis represented a population with widespread Laron syndrome.[4][5]
References
- ↑ Template:WhoNamedIt
- ↑ Laron Z, Pertzelan A, Mannheimer S (1966). "Genetic pituitary dwarfism with high serum concentation of growth hormone--a new inborn error of metabolism?". Isr. J. Med. Sci. 2 (2): 152–5. PMID 5916640.
- ↑ Laron Z (2004). "Laron syndrome (primary growth hormone resistance or insensitivity): the personal experience 1958-2003". J. Clin. Endocrinol. Metab. 89 (3): 1031–44. PMID 15001582.
- ↑ Hershkovitz I, Kornreich L, Laron Z (2007). "Comparative skeletal features between Homo floresiensis and patients with primary growth hormone insensitivity (Laron syndrome)". Am. J. Phys. Anthropol. 134 (2): 198–208. doi:10.1002/ajpa.20655. PMID 17596857.
- ↑ Culotta E (2007). "Paleoanthropology. The fellowship of the hobbit". Science. 317 (5839): 740–2. doi:10.1126/science.317.5839.740. PMID 17690271.