Laron syndrome: Difference between revisions

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	Laron syndrome;
	Growth hormone
ICD-10	E34.3
ICD-9	259.4
OMIM	262500 245590
DiseasesDB	7262
MeSH	D046150

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Revision as of 19:59, 19 September 2012

For patient information click here

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Assosciate Editor(s)-In-Chief: Prashanth Saddala M.B.B.S

Synonyms and keywords: Growth Harmone Receptor Deficiency; Growth hormone insensitivity syndrome; pituitary dwarfism II; Laron syndrome due to postreceptor defect; growth hormone insensitivity due to postreceptor defect; Laron-type dwarfism

Diagnosis

Physical Examination

Physical exam findings include:

Treatment

Treatment may include administration of IGF-1.

References

Template:WikiDoc Sources

@@ Line 21: / Line 21: @@
 ==Diagnosis==
-===Symptoms===
-The principal feature of Laron syndrome is abnormally short stature ([[dwarfism]]).
-Symptoms include:
-*Truncal [[obesity]]<ref name="pmid16817829">{{cite journal |author=Laron Z, Ginsberg S, Lilos P, Arbiv M, Vaisman N |title=Body composition in untreated adult patients with Laron syndrome (primary GH insensitivity) |journal=Clin. Endocrinol. (Oxf) |volume=65 |issue=1 |pages=114-7 |year=2006 |pmid=16817829 |doi=10.1111/j.1365-2265.2006.02558.x}}</ref>
-*[[Seizures]] are frequently secondary to [[hypoglycemia]].
-*Some genetic variations have an impact upon intellectual capacity.<ref name="pmid16372230">{{cite journal |author=Shevah O, Kornreich L, Galatzer A, Laron Z |title=The intellectual capacity of patients with Laron syndrome (LS) differs with various molecular defects of the growth hormone receptor gene. Correlation with CNS abnormalities |journal=Horm. Metab. Res. |volume=37 |issue=12 |pages=757-60 |year=2005 |pmid=16372230 |doi=10.1055/s-2005-921097}}</ref>
 ===Physical Examination===
 Physical exam findings include:


Laron syndrome
Growth hormone
ICD-10	E34.3
ICD-9	259.4
OMIM	262500 245590
DiseasesDB	7262
MeSH	D046150