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==Overview==
==Overview==
==History and Symptoms==
==History and Symptoms==
Infants born with congenital hypothyroidism may show no effects, or may display mild effects that often go unrecognized as a problem: excessive sleeping, reduced interest in [[breastfeeding|nursing]], poor muscle tone, low or hoarse cry, infrequent bowel movements, exaggerated [[neonatal jaundice|jaundice]], and low body temperature. If fetal deficiency was severe because of complete absence (athyreosis) of the gland, physical features may include a larger anterior [[fontanel]], persistence of a posterior fontanel, an [[umbilical hernia]], and a large tongue ([[macroglossia]]).  
*Some babies with congenital hypothyroidism do not appear any signs at birth.
 
*Some may have one or more of the following symptoms:
:*[[Weight gain]]  
:*Puffy face
:*Swollen tongue 
:*Hoarse cry
:*Low muscle tone  
:*Cold intolerance
:*Persistent [[constipation]]
:*[[Fatigue]] and [[weakness]]
:*Little to no growth
:*Without therapy, the child later may show signs of neurological impairment.
:*Excessive sleeping
:*Reduced interest in [[breastfeeding|nursing]]
:*Infrequent bowel movements
:*Exaggerated [[neonatal jaundice|jaundice]].


In the era before newborn screening, less than half of cases of severe hypothyroidism were recognized in the first month of life. As the months proceeded, these infants would grow poorly and be delayed in their development. By several years of age, they would display the recognizable facial and body features of cretinism. Persistence of severe, untreated hypothyroidism resulted in severe mental impairment, with an [[IQ]] below 80 in the majority. Most of these children eventually ended up in institutional care.
In the era before newborn screening, less than half of cases of severe hypothyroidism were recognized in the first month of life. As the months proceeded, these infants would grow poorly and be delayed in their development. By several years of age, they would display the recognizable facial and body features of cretinism. Persistence of severe, untreated hypothyroidism resulted in severe mental impairment, with an [[IQ]] below 80 in the majority. Most of these children eventually ended up in institutional care.
==References==
==References==
{{reflist|2}}
{{reflist|2}}

Revision as of 16:28, 20 September 2012

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

History and Symptoms

  • Some babies with congenital hypothyroidism do not appear any signs at birth.
  • Some may have one or more of the following symptoms:
  • Weight gain
  • Puffy face
  • Swollen tongue
  • Hoarse cry
  • Low muscle tone
  • Cold intolerance
  • Persistent constipation
  • Fatigue and weakness
  • Little to no growth
  • Without therapy, the child later may show signs of neurological impairment.
  • Excessive sleeping
  • Reduced interest in nursing
  • Infrequent bowel movements
  • Exaggerated jaundice.

In the era before newborn screening, less than half of cases of severe hypothyroidism were recognized in the first month of life. As the months proceeded, these infants would grow poorly and be delayed in their development. By several years of age, they would display the recognizable facial and body features of cretinism. Persistence of severe, untreated hypothyroidism resulted in severe mental impairment, with an IQ below 80 in the majority. Most of these children eventually ended up in institutional care.

References

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