Hemolytic disease of the newborn laboratory findings: Difference between revisions
Jump to navigation
Jump to search
No edit summary |
No edit summary |
||
Line 29: | Line 29: | ||
The [[diagnosis]] of HDN is based on history and laboratory findings: | The [[diagnosis]] of HDN is based on history and laboratory findings: | ||
===Blood tests done on the newborn baby=== | |||
* Biochemistry tests for [[jaundice]] | * Biochemistry tests for [[jaundice]] | ||
* Peripheral blood [[morphology (biology)|morphology]] shows increased [[reticulocyte]]s. [[Erythroblast]]s (also known as nucleated red blood cells) occur in moderate and severe disease. | * Peripheral blood [[morphology (biology)|morphology]] shows increased [[reticulocyte]]s. [[Erythroblast]]s (also known as nucleated red blood cells) occur in moderate and severe disease. | ||
* Positive [[Coombs test#Direct Coombs test|direct Coombs test]] (might be negative after fetal interuterine blood transfusion) | * Positive [[Coombs test#Direct Coombs test|direct Coombs test]] (might be negative after fetal interuterine blood transfusion) | ||
===Blood tests done on the mother=== | |||
* Positive [[Coombs test#indirect Coombs test|indirect Coombs test]] | * Positive [[Coombs test#indirect Coombs test|indirect Coombs test]] | ||
Revision as of 13:07, 21 September 2012
Hemolytic disease of the newborn Microchapters |
Differentiating Hemolytic disease of the newborn from other Diseases |
---|
Diagnosis |
Treatment |
Case Studies |
Hemolytic disease of the newborn laboratory findings On the Web |
American Roentgen Ray Society Images of Hemolytic disease of the newborn laboratory findings |
Hemolytic disease of the newborn laboratory findings in the news |
Blogs on Hemolytic disease of the newborn laboratory findings |
Directions to Hospitals Treating Hemolytic disease of the newborn |
Risk calculators and risk factors for Hemolytic disease of the newborn laboratory findings |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Laboratory Findings
- ABO system
- ABO hemolytic disease of the newborn can range from mild to severe, but generally it is a mild disease.
- anti-A antibodies
- anti-B antibodies
- ABO hemolytic disease of the newborn can range from mild to severe, but generally it is a mild disease.
- Rhesus system (the Rh d antigen and Rh d antibodies do not exist)
- rhesus D hemolytic disease of the newborn (often called Rh disease) is the most common form of severe HDN. The disease varies from mild to severe.
- rhesus E hemolytic disease of the newborn is a mild condition
- rhesus c hemolytic disease of the newborn can range from a mild to severe disease - is the third most common form of severe HDN
- rhesus e hemolytic disease of the newborn - rare
- rhesus C hemolytic disease of the newborn - rare
- antibody combinations (ie anti-Rhc and anti-RhE antibodies occurring together) - can be severe
- Kell system
- anti-Kell hemolytic disease of the newborn
- anti-K 1 antibodies - disease ranges from mild to severe - over half of the cases are caused by multiple blood transfusions - is the second most common form of severe HDN
- anti-K 2 ,anti-K 3 and anti-K 4 antibodies - rare
- anti-Kell hemolytic disease of the newborn
- Other blood group antibodies (Kidd, Lewis, Duffy, MN, P and others).
The diagnosis of HDN is based on history and laboratory findings:
Blood tests done on the newborn baby
- Biochemistry tests for jaundice
- Peripheral blood morphology shows increased reticulocytes. Erythroblasts (also known as nucleated red blood cells) occur in moderate and severe disease.
- Positive direct Coombs test (might be negative after fetal interuterine blood transfusion)
Blood tests done on the mother
- Positive indirect Coombs test