Hemolytic-uremic syndrome medical therapy: Difference between revisions
Created page with "__NOTOC__ {{HUS}} {{CMG}} ==Overview== ==Medical Therapy== Treatment is generally supportive with dialysis as needed. Platelet transfusion may a..." |
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In severe cases or when there is diagnostic uncertainty between HUS and [[Thrombotic thrombocytopenic purpura|TTP]], [[plasmapheresis]] is the treatment of choice. | In severe cases or when there is diagnostic uncertainty between HUS and [[Thrombotic thrombocytopenic purpura|TTP]], [[plasmapheresis]] is the treatment of choice. | ||
Antibiotic treatment of O157:H7 colitis may stimulate further verotoxin production and thereby increase the risk of HUS.<ref>http://www.emedicine.com/EMERG/topic238.htm</ref> | Antibiotic treatment of O157:H7 [[colitis]] may stimulate further [[verotoxin]] production and thereby increase the risk of HUS.<ref>http://www.emedicine.com/EMERG/topic238.htm</ref> | ||
:*Plasma exchange daily until LDH normal and platelets stable | :*[[Plasma exchange]] daily until [[LDH]] normal and platelets stable | ||
:*Renal pathology may not entirely resolve (no data on continued plasma exchange after platelets and markers of hemolysis have resolved) | :*Renal pathology may not entirely resolve (no data on continued plasma exchange after platelets and markers of hemolysis have resolved) | ||
:*Average 7-16 exchanges required to induce remission | :*Average 7-16 exchanges required to induce remission | ||
:*Caution plasmapheresis-associated thrombocytopenia (more with certain instruments) | :*Caution plasmapheresis-associated thrombocytopenia (more with certain instruments) | ||
:*Cryopoor plasma exchange not better than regular FFP | :*Cryopoor plasma exchange not better than regular FFP | ||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
Revision as of 13:17, 21 September 2012
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Hemolytic-uremic syndrome Microchapters |
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Differentiating Hemolytic-uremic syndrome from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Medical Therapy
Treatment is generally supportive with dialysis as needed. Platelet transfusion may actually worsen outcome.
In severe cases or when there is diagnostic uncertainty between HUS and TTP, plasmapheresis is the treatment of choice.
Antibiotic treatment of O157:H7 colitis may stimulate further verotoxin production and thereby increase the risk of HUS.[1]
- Plasma exchange daily until LDH normal and platelets stable
- Renal pathology may not entirely resolve (no data on continued plasma exchange after platelets and markers of hemolysis have resolved)
- Average 7-16 exchanges required to induce remission
- Caution plasmapheresis-associated thrombocytopenia (more with certain instruments)
- Cryopoor plasma exchange not better than regular FFP