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{{CMG}}
{{CMG}}
==Overview==
==Overview==
==Epidemiology and Demographics==
===Prevalence of various inherited thrombophilias and their clinical impact===
{| border="1" cellpadding="5" cellspacing="0" align="center" class="sortable"
|-
  ! Disorder
  ! Healthy subjects/General population (%)
  ! Patients with known thrombosis (%)
  ! Estimated increase in thrombosis risk
|-
  | [[Antithrombin deficiency]]
  | 0.02
  | 1 - 4
  | 10 - 20X
|-
  | [[Dysfibrinogenemia]]
  | <1
  | <1
  | Variable
|-
  | [[Protein C deficiency]]
  | 0.2 - 0.4
  | 3 - 5
  | 10X
|-
  | [[Protein S deficiency]]
  | 0.3 - 0.13
  | 2 - 4
  | 10X
|-
  | [[Factor V Leiden]]
  | 1 - 15
  | 18 - 40
  | 5X
|-
  | G20210A [[prothrombin]] gene mutation
  | 2 - 5
  | 7 - 16
  | 3X
|-
  | [[Hyperhomocystenemia]]
  | 5
  | 10
  | 3X
|-
  | Elevated [[factor VIII]] levels
  | 11
  | 25
  | 5X
|-
|}
The table has been adapted from Best Pract Res Clin Obstet Gynaecol. 2003 Jun;17(3):397-411<ref name="pmid12787534">{{cite journal |author=Buchanan GS, Rodgers GM, Ware Branch D |title=The inherited thrombophilias: genetics, epidemiology, and laboratory evaluation |journal=Best Pract Res Clin Obstet Gynaecol |volume=17 |issue=3 |pages=397–411 |year=2003 |month=June |pmid=12787534 |doi= |url=}}</ref> and data has been obtained from references<ref name="pmid11309638">{{cite journal |author=Seligsohn U, Lubetsky A|title=Genetic susceptibility to venous thrombosis |journal=N. Engl. J. Med. |volume=344 |issue=16 |pages=1222–31 |year=2001 |month=April |pmid=11309638|doi=10.1056/NEJM200104193441607 |url=}}</ref><ref name="pmid11702218">{{cite journal |author=Franco RF, Reitsma PH |title=Genetic risk factors of venous thrombosis |journal=Hum. Genet. |volume=109 |issue=4 |pages=369–84 |year=2001 |month=October |pmid=11702218 |doi=10.1007/s004390100593 |url=}}</ref><ref name="pmid7740487">{{cite journal |author=Haverkate F, Samama M |title=Familial dysfibrinogenemia and thrombophilia. Report on a study of the SSC Subcommittee on Fibrinogen |journal=Thromb. Haemost. |volume=73 |issue=1 |pages=151–61 |year=1995 |month=January |pmid=7740487 |doi= |url=}}</ref>.
==References==
==References==
{{reflist|2}}
{{reflist|2}}

Revision as of 13:22, 21 September 2012

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Epidemiology and Demographics

Prevalence of various inherited thrombophilias and their clinical impact

Disorder Healthy subjects/General population (%) Patients with known thrombosis (%) Estimated increase in thrombosis risk
Antithrombin deficiency 0.02 1 - 4 10 - 20X
Dysfibrinogenemia <1 <1 Variable
Protein C deficiency 0.2 - 0.4 3 - 5 10X
Protein S deficiency 0.3 - 0.13 2 - 4 10X
Factor V Leiden 1 - 15 18 - 40 5X
G20210A prothrombin gene mutation 2 - 5 7 - 16 3X
Hyperhomocystenemia 5 10 3X
Elevated factor VIII levels 11 25 5X

The table has been adapted from Best Pract Res Clin Obstet Gynaecol. 2003 Jun;17(3):397-411[1] and data has been obtained from references[2][3][4].

References

  1. ↑ Buchanan GS, Rodgers GM, Ware Branch D (2003). "The inherited thrombophilias: genetics, epidemiology, and laboratory evaluation". Best Pract Res Clin Obstet Gynaecol. 17 (3): 397–411. PMID 12787534. Unknown parameter |month= ignored (help)
  2. ↑ Seligsohn U, Lubetsky A (2001). "Genetic susceptibility to venous thrombosis". N. Engl. J. Med. 344 (16): 1222–31. doi:10.1056/NEJM200104193441607. PMID 11309638. Unknown parameter |month= ignored (help)
  3. ↑ Franco RF, Reitsma PH (2001). "Genetic risk factors of venous thrombosis". Hum. Genet. 109 (4): 369–84. doi:10.1007/s004390100593. PMID 11702218. Unknown parameter |month= ignored (help)
  4. ↑ Haverkate F, Samama M (1995). "Familial dysfibrinogenemia and thrombophilia. Report on a study of the SSC Subcommittee on Fibrinogen". Thromb. Haemost. 73 (1): 151–61. PMID 7740487. Unknown parameter |month= ignored (help)

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