Thrombophilia causes: Difference between revisions
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==Causes of Thrombophilia by Organ System== | ==Causes of Thrombophilia by Organ System== | ||
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|style="height:100px"; style="width:25%" border="1" bgcolor="LightSteelBlue" | '''Cardiovascular''' | |style="height:100px"; style="width:25%" border="1" bgcolor="LightSteelBlue" | '''Cardiovascular''' | ||
Revision as of 13:23, 21 September 2012
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Thrombophilia Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Thrombophilia causes On the Web |
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American Roentgen Ray Society Images of Thrombophilia causes |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Causes
Inherited
Common types:
- G1691A mutation in factor V gene (Factor V, Leiden type; 5% of the population are heterozygous for FVL)
- Prothrombin (factor II) mutation (G20210A, 5'UTR)
- Homozygous C677T mutation in the MTHFR gene
Rare forms:
- Plasminogen and fibrinolysis disorders
- Paroxysmal nocturnal hemoglobinuria
- Protein C deficiency
- Protein S deficiency
- Antithrombin III deficiency
- Dysfibrinogenemia
- Homozygous homocystinuria
- Increased levels of factor VIII, factor IX, factor XI, or fibrinogen.
Acquired
- Antiphospholipid antibodies
- Renal disease (renal loss of antithrombin)
- High homocysteine levels due to vitamin deficiency (vitamins B6, B12 and folic acid).
- Immobility
- Pregnancy and puerperium
- Oral contraceptive pills
- Malignancy
- Obesity
- African American race
- Hormone replacement therapy
- Surgery and trauma
- Older age
- Myeloproliferative disorders
- Previous thrombosis