Erdheim-Chester disease laboratory findings: Difference between revisions
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==Laboratory Findings== | ==Laboratory Findings== | ||
Histologically, ECD differs from Langerhans cell histiocytosis (LCH) in a number of ways. Unlike LCH, ECD does not stain positive for [[S-100 protein|S-100]] or [[CD 1a]], and electron microscopy of cell cytoplasm does not disclose [[Birbeck granules]].<ref name="pmid8965684"> </ref> Tissue samples show xanthomatous or xanthogranulomatous infiltration by lipid-laden or foamy histiocytes, and are usually surrounded by fibrosis. Bone biopsy is said to offer the greatest likelihood of reaching a diagnosis. | Histologically, ECD differs from Langerhans cell histiocytosis (LCH) in a number of ways. Unlike LCH, ECD does not stain positive for [[S-100 protein|S-100]] or [[CD 1a]], and electron microscopy of cell cytoplasm does not disclose [[Birbeck granules]].<ref name="pmid8965684">{{cite journal |author=Veyssier-Belot C, Cacoub P, Caparros-Lefebvre D, ''et al'' |title=Erdheim-Chester disease. Clinical and radiologic characteristics of 59 cases |journal=Medicine (Baltimore) |volume=75 |issue=3 |pages=157-69 |year=1996 |pmid=8965684 |doi=}}</ref> Tissue samples show xanthomatous or xanthogranulomatous infiltration by lipid-laden or foamy histiocytes, and are usually surrounded by fibrosis. Bone biopsy is said to offer the greatest likelihood of reaching a diagnosis. | ||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
Revision as of 13:55, 21 September 2012
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Laboratory Findings
Histologically, ECD differs from Langerhans cell histiocytosis (LCH) in a number of ways. Unlike LCH, ECD does not stain positive for S-100 or CD 1a, and electron microscopy of cell cytoplasm does not disclose Birbeck granules.[1] Tissue samples show xanthomatous or xanthogranulomatous infiltration by lipid-laden or foamy histiocytes, and are usually surrounded by fibrosis. Bone biopsy is said to offer the greatest likelihood of reaching a diagnosis.