Castleman's disease pathophysiology: Difference between revisions
(Created page with "__NOTOC__ {{Castleman's disease}} {{CMG}}; {{AE}} {{RT}} Please help WikiDoc by adding more content here. It's easy! Click here to learn about...") |
No edit summary |
||
| Line 10: | Line 10: | ||
In all cases, Castleman's disease is likely due to hypersecretion of the cytokine [[Interleukin 6|IL-6]]. In KSHV positive tumors, this is most likely due to expression of the a virus-encoded cytokine, vIL-6, while KSHV negative tumors appear to be the result of over secretion of human IL-6.<ref> Aoki Y, Yarchoan R, Wyvill K, Okamoto S, Little RF, Tosato G. Detection of viral interleukin-6 in Kaposi sarcoma-associated herpesvirus-linked disorders. Blood 2001;97(7):2173-6.</ref> | In all cases, Castleman's disease is likely due to hypersecretion of the cytokine [[Interleukin 6|IL-6]]. In KSHV positive tumors, this is most likely due to expression of the a virus-encoded cytokine, vIL-6, while KSHV negative tumors appear to be the result of over secretion of human IL-6.<ref> Aoki Y, Yarchoan R, Wyvill K, Okamoto S, Little RF, Tosato G. Detection of viral interleukin-6 in Kaposi sarcoma-associated herpesvirus-linked disorders. Blood 2001;97(7):2173-6.</ref> | ||
===Associated Conditions=== | |||
Castleman's disease is sometimes associated with: | |||
* [[POEMS syndrome]] | |||
* [[Paraneoplastic pemphigus]] | |||
* [[Thrombotic thrombocytopenic purpura]] ([[TTP]]) | |||
==References== | ==References== | ||
Latest revision as of 14:12, 21 September 2012
|
Castleman's disease Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Castleman's disease pathophysiology On the Web |
|
American Roentgen Ray Society Images of Castleman's disease pathophysiology |
|
Risk calculators and risk factors for Castleman's disease pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [2]
Please help WikiDoc by adding more content here. It's easy! Click here to learn about editing.
Overview
Pathophysiology
In all cases, Castleman's disease is likely due to hypersecretion of the cytokine IL-6. In KSHV positive tumors, this is most likely due to expression of the a virus-encoded cytokine, vIL-6, while KSHV negative tumors appear to be the result of over secretion of human IL-6.[1]
Associated Conditions
Castleman's disease is sometimes associated with:
References
- ↑ Aoki Y, Yarchoan R, Wyvill K, Okamoto S, Little RF, Tosato G. Detection of viral interleukin-6 in Kaposi sarcoma-associated herpesvirus-linked disorders. Blood 2001;97(7):2173-6.