Agranulocytosis laboratory findings: Difference between revisions
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==Overview== | |||
==Laboratory Findings== | |||
The diagnosis is made after a [[complete blood count]], a routine blood test. The absolute neutrophil count in this test will be below 500, and can reach 0 cells/mm³. Other kinds of blood cells are typically present in normal numbers. | |||
To formally diagnose agranulocytosis, other pathologies with a similar presentation must be excluded, such as [[aplastic anemia]], [[paroxysmal nocturnal hemoglobinuria]], [[myelodysplasia]] and [[leukemia]]s. This requires a [[bone marrow examination]] that shows normocellular (normal amounts and types of cells) blood marrow with underdeveloped [[promyelocyte]]s. These underdeveloped promyelocytes, if fully matured, would have been the missing granulocytes. | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
Revision as of 15:57, 21 September 2012
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Laboratory Findings
The diagnosis is made after a complete blood count, a routine blood test. The absolute neutrophil count in this test will be below 500, and can reach 0 cells/mm³. Other kinds of blood cells are typically present in normal numbers.
To formally diagnose agranulocytosis, other pathologies with a similar presentation must be excluded, such as aplastic anemia, paroxysmal nocturnal hemoglobinuria, myelodysplasia and leukemias. This requires a bone marrow examination that shows normocellular (normal amounts and types of cells) blood marrow with underdeveloped promyelocytes. These underdeveloped promyelocytes, if fully matured, would have been the missing granulocytes.