Spherocytosis: Difference between revisions

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Revision as of 16:43, 21 September 2012

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Kumar, Vinay, Abul Abbas, and Nelson Fausto. "Robbins and Cotran Pathologic Basis of Disease, 7th edition (2004)."
Schneider, Arthur S. and Philip A. Stanzo. "Board Review Series: Pathology, 2nd edition (2002)."

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-==Symptoms==
-The [[spleen]]'s [[hemolysis]] results directly in varying degrees of [[anemia]] and hyperbilirubinemia, which in turn result in symptoms of [[Fatigue (physical)|fatigue]], [[pallor]], and [[jaundice]].
-Acute cases can threaten [[Hypoxia (medical)|hypoxemia]] through [[anemia]] and acute [[kernicterus]] through hyperbilirubinemia, particularly in newborns.
-Chronic symptoms include [[anemia]] and [[splenomegaly]], or enlargement of the [[spleen]] due to its [[hypersplenism|increased activity]]. In some cases the spleen continues to change sizes.  Yet in other cases the spleen just continues growing which puts the patient at a greater risk for rupture, which can cause death. Furthermore, the detritus of the broken-down blood cells--[[bilirubin]]--accumulates in the [[gallbladder]], and can cause [[gallstones]] or "sludge" to develop.  In chronic patients, an [[infection]] or other illness can cause an increase in the destruction of red blood cells, resulting in the appearance of acute symptoms, a ''hemolytic crisis''.
 ==See also==