Acute monocytic leukemia: Difference between revisions

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	Acute monocytic leukemia;
ICD-10	C93.0
ICD-9	206.0
MeSH	D007948

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VisualWikitext

Revision as of 19:08, 21 September 2012

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Synonyms and keywords: AMoL; AML-M5

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Acute monocytic leukemia from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Criteria | History and Symptoms | Physical Examination | Laboratory Findings | Other Diagnostic Studies

Treatment

Medical Therapy | Surgery | Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies

Case Studies

Case #1

Template:Hematology

Template:WikiDoc Sources

@@ Line 12: / Line 12: @@
    MeshID         = D007948 |
 }}
-{{Search infobox}}
+{{Acute monocytic leukemia}}
 {{CMG}}
 {{SK}} AMoL; AML-M5
-==Overview==
+==[[Acute monocytic leukemia overview|Overview]]==
-'''Acute monocytic leukemia''' is considered a type of [[acute myeloid leukemia]].
-==Classification==
+==[[Acute monocytic leukemia historical perspective|Historical Perspective]]==
-A further subclassification (M5a versus M5b) is made depending on whether the monocytic cells are predominantly monoblasts (>80%) ('''acute monoblastic leukemia''') or a mixture of monoblasts and promonocytes (<80% blasts).
-==Pathophysiology==
+==[[Acute monocytic leukemia classification|Classification]]==
-===Genetics===
-M5 is associated with characteristic chromosomal abnormalities, often involving 11q23 or t(9;11)affecting the MLL locus, however the MLL translocation is also found in other AML subtypes. MLL is believed to be prognostically unfavorable in AML-M5 compared to other genetic alterations involving MLL such as t(9;11) The t(8;16) translocation in MLL is associated with hemophagocytosis.
-===Immunology===
-Immunophenotypically, M5-AML variably express myeloid ([[CD13]], [[CD33]]) and monocytic ([[CD11b]], [[CD11c]]) markers. Cells may aberrantly express B cels marker [[CD20]] and the NK marker [[CD56]]. Monoblasts may be positive for [[CD34]].
-==Risk Factors==
+==[[Acute monocytic leukemia pathophysiology|Pathophysiology]]==
-AML-M5 is thought to be associated with exposure to epidophyllotoxins.
+==[[Acute monocytic leukemia causes|Causes]]==
+==[[Acute monocytic leukemia differential diagnosis|Differentiating Acute monocytic leukemia from other Diseases]]==
+==[[Acute monocytic leukemia epidemiology and demographics|Epidemiology and Demographics]]==
+==[[Acute monocytic leukemia risk factors|Risk Factors]]==
+==[[Acute monocytic leukemia screening|Screening]]==
+==[[Acute monocytic leukemia natural history, complications and prognosis|Natural History, Complications and Prognosis]]==
 ==Diagnosis==
-===Diagnostic Criteria===
+[[Acute monocytic leukemia criteria|Criteria]] | [[Acute monocytic leukemia history and symptoms|History and Symptoms]] | [[Acute monocytic leukemia physical examination|Physical Examination]] | [[Acute monocytic leukemia laboratory findings|Laboratory Findings]] | [[Acute monocytic leukemia other diagnostic studies|Other Diagnostic Studies]]
-In order to fulfill [[World Health Organization]] (WHO) criteria for AML-5, a patient must have greater than 20% blasts in the bone marrow, and of these, greater than 80% must be of the monocytic lineage.
-===Laboratory Findings===
-*Peripheral Smear
-**[[Monoblasts]] can be distinguished by having a roughly circular nucleus, delicate lacy chromatin, and abundant, often basophilic cytoplasm. These cells may also have pseudopods. By contrast, promonocytes have a more convoluted nucleus, and their cytoplasm may contain metachromatic granules.
-*[[Monoblasts]] are typically [[Myeloperoxidase|MPO]] negative and promonocytes are [[Myeloperoxidase|MPO]] variable. Both [[monoblasts]] and promonocytes stain positive for non-specific [[esterase]] (NSE), however [[Esterase|NSE]] may often be negative.
 ==Treatment==
-AML-M5 is treated with intensive chemotherapy (such as anthracyclines) or with [[bone marrow transplantation]].
+[[Acute monocytic leukemia medical therapy|Medical Therapy]] | [[Acute monocytic leukemia surgery|Surgery]] | [[Acute monocytic leukemia prevention|Prevention]] | [[Acute monocytic leukemia cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[Acute monocytic leukemia future or investigational therapies|Future or Investigational Therapies]]
+==Case Studies==
-==References==
+[[Acute monocytic leukemia case study one|Case #1]]
-{{reflist|2}}
 {{Hematology}}

v t e Myeloid Hematological malignancy/leukemia histology (ICD-O 9590-9989, C81-C96, 200-208)
CFU-GM/ and other granulocytes	Template:Navbox subgroup
MEP	Template:Navbox subgroup
CFU-Mast	Mastocytoma (Mast cell leukemia, Mast cell sarcoma, Systemic mastocytosis)
Multiple/unknown	AML (Acute panmyelosis with myelofibrosis, Myeloid sarcoma) · MP (Myelofibrosis) · Acute biphenotypic leukaemia
See also hematology, lymphoid malignancy

Acute monocytic leukemia
ICD-10	C93.0
ICD-9	206.0
MeSH	D007948

Acute monocytic leukemia: Difference between revisions

Revision as of 19:08, 21 September 2012

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