ARVD1: Difference between revisions
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==Epidemiology and Demographics== | ==Epidemiology and Demographics== | ||
The incidence of ARVD is about 1/10,000 in the general population in the [[United States]], although some studies have suggested that it may be as common as 1/1,000. It accounts for up to 17% of all sudden cardiac deaths in the young. In [[Italy]], the incidence is 40/10,000, making it the most common cause of [[sudden cardiac death]] in the young population. It is more common in Northern Italy. | |||
===Gender=== | |||
The male to female ratio is 3:1. | |||
==Natural History, Complications, Prognosis== | ==Natural History, Complications, Prognosis== |
Revision as of 01:34, 23 September 2012
Arrhythmogenic right ventricular dysplasia Microchapters |
Differentiating Arrhythmogenic right ventricular dysplasia from other Diseases |
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Diagnosis |
Treatment |
ARVD1 On the Web |
American Roentgen Ray Society Images of ARVD1 |
Directions to Hospitals Treating Arrhythmogenic right ventricular dysplasia |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Synonyms and keywords: Arrhythmogenic right ventricular dysplasia type 1;
Overview
Pathophysiology
The pathogenesis of ARVD involves apoptosis with fatty and fibro-fatty infiltration of the right ventricular free wall leading to heart failure and ventricular arrhythmias.
Genetics
There is an autosomal dominant pattern of inheritance. This variant is due to a heterozygous mutation in the TGFB3 gene (190230) on chromosome 14q24.
Epidemiology and Demographics
The incidence of ARVD is about 1/10,000 in the general population in the United States, although some studies have suggested that it may be as common as 1/1,000. It accounts for up to 17% of all sudden cardiac deaths in the young. In Italy, the incidence is 40/10,000, making it the most common cause of sudden cardiac death in the young population. It is more common in Northern Italy.
Gender
The male to female ratio is 3:1.