Berylliosis

Template:DiseaseDisorder infobox Template:Search infobox Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Synonyms and keywords: Chronic beryllium disorder; CBD

Overview

Berylliosis or chronic beryllium disorder (CBD) is an occupational lung disease. It is a chronic allergic-type lung response and chronic lung disease caused by exposure to beryllium and its compounds. The condition is incurable but symptoms can be treated.

Classification

Granulomas are seen in other chronic diseases, such as tuberculosis, sarcoidosis, and it can occasionally be hard to distinguish berylliosis from these disorders.

Pathophysiology

With single or prolonged exposure by inhalation, the lungs become hypersensitive to beryllium causing the development of small inflammatory nodules, called granulomas.

Natural History, Complications, and Prognosis

Natural History

Ultimately, this process leads to restrictive lung disease, a decreased diffusion capacity.

Complications

Rarely, one can get granulomas in other organs including the liver.

Diagnosis

Symptoms

Clinically patients experience cough and shortness of breath. Other symptoms include chest pain, joint aches, weight loss and fever.

The onset of symptoms can range from weeks up to tens of years from the initial exposure. In some individuals a single exposure can cause berylliosis.

References

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