Carcinoid syndrome overview: Difference between revisions
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==Overview== | ==Overview== | ||
'''Carcinoid''' (also '''carcinoid tumour''' or '''carcinoid tumor''') is slow-growing but often [[malignant]] type of [[neuroendocrine tumour]], originating in the cells of the [[neuroendocrine system]]. Carcinoid tumours are [[apudomas]] that arise from the [[enterochromaffin cell]]s throughout the gut. They are most commonly found in the [[foregut]] (35.6% cases) with [[lung]], [[bronchus]] and [[trachea]] constituting 27.9% cases from where they rarely [[metastasis]]e (except in case of pancreas). The next most common affected area is the small intestine especially the midgut (32.1% cases) with the highest proportion from [[ileum]] at 14.9% of all cases [as per the PAN-SEER data (1973-1999)]. In cases of metastases it can lead to [[carcinoid syndrome]]. This is due to the production of [[serotonin]], which is released into the systemic circulation, which leads to symptoms of cutaneous flushing, [[diarrhea]], [[bronchoconstriction]] and right-sided [[cardiac]] [[heart valve disease|valve disease]]. | '''Carcinoid''' (also '''carcinoid tumour''' or '''carcinoid tumor''') is slow-growing but often [[malignant]] type of [[neuroendocrine tumour]], originating in the cells of the [[neuroendocrine system]]. Carcinoid tumours are [[apudomas]] that arise from the [[enterochromaffin cell]]s throughout the gut. They are most commonly found in the [[foregut]] (35.6% cases) with [[lung]], [[bronchus]] and [[trachea]] constituting 27.9% cases from where they rarely [[metastasis]]e (except in case of pancreas). The next most common affected area is the small intestine especially the midgut (32.1% cases) with the highest proportion from [[ileum]] at 14.9% of all cases [as per the PAN-SEER data (1973-1999)]. In cases of metastases it can lead to [[carcinoid syndrome]]. This is due to the production of [[serotonin]], which is released into the systemic circulation, which leads to symptoms of cutaneous flushing, [[diarrhea]], [[bronchoconstriction]] and right-sided [[cardiac]] [[heart valve disease|valve disease]]. | ||
==References== | ==References== | ||
Revision as of 16:18, 25 September 2012
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Carcinoid syndrome Microchapters |
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Carcinoid syndrome overview On the Web |
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American Roentgen Ray Society Images of Carcinoid syndrome overview |
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Risk calculators and risk factors for Carcinoid syndrome overview |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Carcinoid (also carcinoid tumour or carcinoid tumor) is slow-growing but often malignant type of neuroendocrine tumour, originating in the cells of the neuroendocrine system. Carcinoid tumours are apudomas that arise from the enterochromaffin cells throughout the gut. They are most commonly found in the foregut (35.6% cases) with lung, bronchus and trachea constituting 27.9% cases from where they rarely metastasise (except in case of pancreas). The next most common affected area is the small intestine especially the midgut (32.1% cases) with the highest proportion from ileum at 14.9% of all cases [as per the PAN-SEER data (1973-1999)]. In cases of metastases it can lead to carcinoid syndrome. This is due to the production of serotonin, which is released into the systemic circulation, which leads to symptoms of cutaneous flushing, diarrhea, bronchoconstriction and right-sided cardiac valve disease.