Atrioventricular septal defect differential diagnosis: Difference between revisions

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==Epidemiology and demographics==
In the US, the prevalence of atrioventricular septal defects is between 3-5% in live births or about 0.19 per 1000 live births. The incidence of AVSD is higher in stillborn births, at a rate of approximately 7%. One explanation for this increase is this population's propensity for chromosal and other anomalies. Of live births, approximately 45% of infants with Down syndrome and congenital heart disease have an atrioventricular canal defect. Atrioventricular septal defects are distributed about equal between males and females.<ref name="pmid2063835">{{cite journal| author=Rosenthal GL, Wilson PD, Permutt T, Boughman JA, Ferencz C| title=Birth weight and cardiovascular malformations: a population-based study. The Baltimore-Washington Infant Study. | journal=Am J Epidemiol | year= 1991 | volume= 133 | issue= 12 | pages= 1273-81 | pmid=2063835 | doi= | pmc= | url= }} </ref>
 
There is some evidence to suggest a potential link between atrioventricular septal defects and familial clustering. Approximately 14% of women with a common atrioventricular canal pass on the congenital heart disease to their children. In one analysis, 11.7% of children with atrioventricular septal defects had a family history of congenital heart disease<ref name="pmid8249947">{{cite journal| author=Digilio MC, Marino B, Cicini MP, Giannotti A, Formigari R, Dallapiccola B| title=Risk of congenital heart defects in relatives of patients with atrioventricular canal. | journal=Am J Dis Child | year= 1993 | volume= 147 | issue= 12 | pages= 1295-7 | pmid=8249947 | doi= | pmc= | url= }} </ref>
 
There is no epidemiological evidence to support any variation of incidence and prevalence based on race, sex or age. Onset is generally early in life, occurring within the first 6 weeks of life. In rare cases, patients can be asymptomatic during development and may experience a latent onset as [[cyanosis]] develops into a severe complication.


==References==
==References==
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Revision as of 13:56, 1 October 2012

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